| Cardiac Noradrenergic Denervation in a Patient with Multiple Symmetric Lipomatosis. | |
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MedLine Citation:
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PMID: 22441442 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Multiple symmetric lipomatosis (MSL) is a rare disease of unknown etiology characterized by multiple subcutaneous lipomas with a symmetrical distribution. One interesting aspect about MSL is a high incidence of sudden cardiac death despite a low incidence of metabolic syndrome and coronary arterial disease. Autonomic nervous system dysfunction may probably explain this feature of MSL. Case Report: A 74-year-old man was admitted with acute heart failure and atrial fibrillation. He had a morphotype suggestive of MLS. A (123)I-metaiodobenzylguanidine myocardial scintigraphy was conducted for evaluation of cardiac autonomic nervous integrity, since atrial fibrillation precluded the classical approach. The heart-to-mediastinum ratio was 1.68 (normal >2.2). Ischemia was not detected in myocardial perfusion scintigraphy. Conclusion: We present the first reported case of MSL autonomic neuropathy detected by (123)I- metaiodobenzylguanidine scintigraphy and suggest that this approach could play a role in MSL stratification by risk of sudden cardiac death and in exploring MSL disease mechanisms. |
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Authors:
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Válter R Fonseca; Carlos Freitas; Mireille Palmeira; Carlos Ferreira; Rui Victorino |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-22 |
Journal Detail:
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Title: Cardiology Volume: 121 ISSN: 1421-9751 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: - |
Other Details:
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Languages: ENG Pagination: 160-163 Citation Subset: - |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Clínica Universitária de Medicina II, CHLN - Hospital de Santa Maria, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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