Document Detail


Cardiac micro-computed tomography imaging of the aging coronary vasculature.
MedLine Citation:
PMID:  22679058     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Alterations at the level of the coronary circulation with aging may play an important role in the evolution of age-associated changes in left ventricular (LV) fibrosis and function. However these age-associated changes in the coronary vasculature remain poorly defined primarily due to the lack of high resolution imaging technologies. The current study was designed to utilize cardiac micro-computed tomography (micro-CT) technology as a novel imaging strategy, to define the 3-dimensional coronary circulation in the young and aged heart and its relationship to LV fibrosis and function.
METHODS AND RESULTS: Young (2 months old; n=10) and aged (20 months old; n=10) Fischer rats underwent cardiac micro-CT imaging as well as echocardiography, blood pressure, and fibrosis analysis. Importantly, when indexed to LV mass, which increased with age, the total and intramyocardial vessel volumes were lower, whereas the epicardial vessel volume, with and without indexing to LV mass, was significantly higher in the aged hearts compared with the young hearts. Moreover, the aged hearts had a significantly lower percentage of intramyocardial vessel volume and a significantly higher percentage of epicardial vessel volume, when normalized to the total vessel volume, compared with the young hearts. Further, the aged hearts had significant LV fibrosis and mild LV dysfunction compared with the young hearts.
CONCLUSIONS: This micro-CT imaging study reports the reduction in normalized intramyocardial vessel volume within the aged heart, in association with increased epicardial vessel volume, in the setting of increased LV fibrosis, and mild LV dysfunction.
Authors:
S Jeson Sangaralingham; Erik L Ritman; Paul M McKie; Tomoko Ichiki; Amir Lerman; Christopher G Scott; Fernando L Martin; Gerald E Harders; Diego Bellavia; John C Burnett
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-07
Journal Detail:
Title:  Circulation. Cardiovascular imaging     Volume:  5     ISSN:  1942-0080     ISO Abbreviation:  Circ Cardiovasc Imaging     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-19     Completed Date:  2012-10-24     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101479935     Medline TA:  Circ Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  518-24     Citation Subset:  IM    
Affiliation:
Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA. sangaralingham.jeson@mayo.edu
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Blood Pressure / physiology
Coronary Circulation*
Echocardiography
Fibrosis / physiopathology,  radiography,  ultrasonography
Imaging, Three-Dimensional
Linear Models
Rats
Rats, Inbred F344
Ventricular Dysfunction, Left / physiopathology*,  radiography*,  ultrasonography
X-Ray Microtomography*
Grant Support
ID/Acronym/Agency:
P01 HL076611/HL/NHLBI NIH HHS; P01 HL76611/HL/NHLBI NIH HHS; R01 EB000305/EB/NIBIB NIH HHS; R01 EB000305/EB/NIBIB NIH HHS; R01 HL036634/HL/NHLBI NIH HHS; R01 HL083231/HL/NHLBI NIH HHS; R01 HL36634/HL/NHLBI NIH HHS; R01 HL83231/HL/NHLBI NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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