| Cardiac MRI evaluation of hypertrophic cardiomyopathy: left ventricular outflow tract/aortic valve diameter ratio predicts severity of LVOT obstruction. | |
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MedLine Citation:
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PMID: 22549972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate if left ventricular outflow tract/aortic valve (LVOT/AO) diameter ratio measured by cardiac magnetic resonance (CMR) imaging is an accurate marker for LVOT obstruction in patients with hypertrophic cardiomyopathy (HCM) compared to Doppler echocardiography. MATERIALS AND METHODS: In all, 92 patients with HCM were divided into three groups based on their resting echocardiographic LVOT pressure gradient (PG): <30 mmHg at rest (nonobstructive, n = 31), <30 mmHg at rest, >30 mmHg after provocation (latent, n = 29), and >30 mmHg at rest (obstructive, n = 32). The end-systolic dimension of the LVOT on 3-chamber steady-state free precession (SSFP) CMR was divided by the end diastolic aortic valve diameter to calculate the LVOT/AO diameter ratio. RESULTS: There were significant differences in the LVOT/AO diameter ratio among the three subgroups (nonobstructive 0.60 ± 0.13, latent 0.41 ± 0.16, obstructive 0.24 ± 0.09, P < 0.001). There was a strong linear inverse correlation between the LVOT/AO diameter ratio and the log of the LVOT pressure gradient (r = -0.84, P < 0.001). For detection of a resting gradient >30 mmHg, the LVOT/AO diameter ratio the area under the receiver operating characteristic (ROC) curve was 0.91 (95% confidence interval [CI] 0.85-0.97). For detection of a resting and/or provoked gradient >30 mmHg, the LVOT/AO diameter ratio area under the ROC curve was 0.90 (95% CI 0.84-0.96). CONCLUSION: The LVOT/AO diameter ratio is an accurate, reproducible, noninvasive, and easy to use CMR marker to assess LVOT pressure gradients in patients with HCM. |
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Authors:
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Jens Vogel-Claussen; Miguel Santaularia Tomas; Amit Newatia; Danielle Boyce; Aurelio Pinheiro; Roselle Abraham; Theodore Abraham; David A Bluemke |
Publication Detail:
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Type: Journal Article Date: 2012-05-01 |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 36 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-08-20 Completed Date: 2013-01-18 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 598-603 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. vogel-claussen.jens@mh-hannover.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Aorta / pathology* Cardiomyopathy, Hypertrophic / complications, pathology* Female Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Magnetic Resonance Imaging, Cine / methods* Male Middle Aged Reproducibility of Results Sensitivity and Specificity Severity of Illness Index Ventricular Outflow Obstruction / etiology*, pathology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL098046-01/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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