Document Detail

Cardiac PET/CT for the evaluation of known or suspected coronary artery disease.
MedLine Citation:
PMID:  21918042     Owner:  NLM     Status:  MEDLINE    
Positron emission tomography (PET) is increasingly being applied in the evaluation of myocardial perfusion. Cardiac PET can be performed with an increasing variety of cyclotron- and generator-produced radiotracers. Compared with single photon emission computed tomography, PET offers lower radiation exposure, fewer artifacts, improved spatial resolution, and, most important, improved diagnostic performance. With its capacity to quantify rest-peak stress left ventricular systolic function as well as coronary flow reserve, PET is superior to other methods for the detection of multivessel coronary artery disease and, potentially, for risk stratification. Coronary artery calcium scoring may be included for further risk stratification in patients with normal perfusion imaging findings. Furthermore, PET allows quantification of absolute myocardial perfusion, which also carries substantial prognostic value. Hybrid PET-computed tomography scanners allow functional evaluation of myocardial perfusion combined with anatomic characterization of the epicardial coronary arteries, thereby offering great potential for both diagnosis and management. Additional studies to further validate the prognostic value and cost effectiveness of PET are warranted.
Marcelo F Di Carli; Venkatesh L Murthy
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiographics : a review publication of the Radiological Society of North America, Inc     Volume:  31     ISSN:  1527-1323     ISO Abbreviation:  Radiographics     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-09-15     Completed Date:  2012-01-20     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8302501     Medline TA:  Radiographics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1239-54     Citation Subset:  IM    
Department of Radiology, Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Calcinosis / radionuclide imaging
Coronary Artery Disease / radionuclide imaging
Coronary Disease / radionuclide imaging*
Heart / radionuclide imaging*
Myocardial Perfusion Imaging / methods
Positron-Emission Tomography and Computed Tomography* / instrumentation,  methods
Radiopharmaceuticals / diagnostic use
Risk Assessment
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon
Ventricular Dysfunction, Left / radionuclide imaging
Reg. No./Substance:

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