Document Detail

Cardiac disease associated with increased risk of nonamnestic cognitive impairment: stronger effect on women.
MedLine Citation:
PMID:  23358884     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the association of cardiac disease with amnestic and nonamnestic mild cognitive impairment (aMCI and naMCI, respectively). Nonamnestic mild cognitive impairment, a putative precursor of vascular and other non-Alzheimer dementias, is hypothesized to have a vascular etiology.
DESIGN: A prospective, population-based, cohort study with a median 4.0 years of follow-up.
SETTING: Olmsted County, Minnesota.
PARTICIPANTS: A total of 2719 participants were evaluated at baseline and every 15 months using the Clinical Dementia Rating scale, a neurological evaluation, and neuropsychological testing. A diagnosis of normal cognition, MCI, or dementia was made by consensus. Cardiac disease at baseline was assessed from the participant's medical records.
RESULTS: Of 1450 participants without MCI or dementia at baseline, 366 developed MCI. Cardiac disease was associated with an increased risk of naMCI (hazard ratio, 1.77 [95% CI, 1.16-2.72]). However, the association varied by sex (P = .02 for interaction). Cardiac disease was associated with an increased risk of naMCI (hazard ratio, 3.07 [95% CI, 1.58-5.99]) for women but not for men (hazard ratio, 1.16 [95% CI, 0.68-1.99]). Cardiac disease was not associated with any type of MCI or with aMCI.
CONCLUSIONS: Cardiac disease is an independent risk factor for naMCI; within-sex comparisons showed a stronger association for women. Prevention and management of cardiac disease and vascular risk factors may reduce the risk of naMCI.
Rosebud O Roberts; Yonas E Geda; David S Knopman; Ruth H Cha; V Shane Pankratz; Bradley F Boeve; Eric G Tangalos; Robert J Ivnik; Michelle M Mielke; Ronald C Petersen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JAMA neurology     Volume:  70     ISSN:  2168-6157     ISO Abbreviation:  JAMA Neurol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-12     Completed Date:  2013-04-29     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  101589536     Medline TA:  JAMA Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374-82     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Cognition Disorders / diagnosis*,  epidemiology*,  psychology
Cohort Studies
Follow-Up Studies
Heart Diseases / diagnosis*,  epidemiology*,  psychology
Longitudinal Studies
Population Surveillance / methods
Prospective Studies
Risk Factors
Sex Factors
Grant Support
K01 AG028573/AG/NIA NIH HHS; K01 AG028573/AG/NIA NIH HHS; K01 MH068351/MH/NIMH NIH HHS; K01 MH068351/MH/NIMH NIH HHS; P50 AG016574/AG/NIA NIH HHS; P50 AG016574/AG/NIA NIH HHS; R01 AG011378/AG/NIA NIH HHS; R01 AG034676/AG/NIA NIH HHS; R01 AG034676/AG/NIA NIH HHS; U01 AG006786/AG/NIA NIH HHS; U01 AG006786/AG/NIA NIH HHS

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