| The Cardiac Copper Chaperone Proteins Sco1 and CCS are Up-Regulated, but Cox 1 and Cox4 are Down-Regulated, by Copper Deficiency. | |
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MedLine Citation:
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PMID: 20878365 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Copper is ferried in a cell complexed to chaperone proteins, and in the heart much copper is required for cytochrome c oxidase (Cox). It is not completely understood how copper status affects the levels of these proteins. Here we determined if dietary copper deficiency could up- or down-regulate select copper chaperone proteins and Cox subunits 1 and 4 in cardiac tissue of rats. Sixteen weanling male Long-Evans rats were randomized into treatment groups, one group receiving a copper-deficient diet (<1 mg Cu/kg diet) and one group receiving a diet containing adequate copper (6 mg Cu/kg diet) for 5 weeks. Hearts were removed, weighed, and non-myofibrillar proteins separated to analyze for levels of CCS, Sco1, Ctr1, Cox17, Cox1, and Cox4 by SDS-PAGE and Western blotting. No changes were observed in the concentrations of CTR1 and Cox17 between copper-adequate and copper-deficient rats. CCS and Sco1 were up-regulated and Cox1 and Cox4 were both down-regulated as a result of copper deficiency. These data suggest that select chaperone proteins and may be up-regulated, and Cox1 and 4 down-regulated, by a dietary copper deficiency, whereas others appear not to be affected by copper status. |
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Authors:
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Jean Getz; Dingbo Lin; Denis M Medeiros |
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Publication Detail:
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Type: Journal Article Date: 2010-09-28 |
Journal Detail:
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Title: Biological trace element research Volume: 143 ISSN: 1559-0720 ISO Abbreviation: Biol Trace Elem Res Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: United States |
Other Details:
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Languages: eng Pagination: 368-77 Citation Subset: IM |
Affiliation:
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Department of Human Nutrition, Kansas State University, 213 Justin Hall, Manhattan, KS, 66506, USA, jeangetz@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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