| Cardiac Baroreflex Function and Dynamic Cerebral Autoregulation In Elderly Masters Athletes. | |
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MedLine Citation:
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PMID: 23139365 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose: Cerebral blood flow (CBF) is maintained stable through combined effects of blood pressure (BP) regulation and cerebral autoregulation. Previous studies suggest that aerobic exercise training improves cardiac baroreflex function and beneficially affects BP regulation, but may negatively affect cerebral autoregulation. The purpose of this study was to reveal the impact of lifelong exercise on cardiac baroreflex function and dynamic cerebral autoregulation (dCA) in older adults. Methods: Eleven Masters athletes (MA) (8 males, 3 females, mean age 73±6 yrs, aerobic training >15 yrs) and 12 healthy sedentary elderly (SE) (7 males, 5 females, mean age 71±6 yrs) participated in this study. BP, CBF velocity (CBFV) and heart rate were measured during resting conditions and repeated sit-stand maneuvers to enhance BP variability. Baroreflex gain was assessed using transfer function analysis of spontaneous changes in systolic BP and R-R interval in the low frequency range (0.05-0.15 Hz). dCA was assessed during sit-stand induced changes in mean BP and CBFV at 0.05 Hz (10s sit, 10s stand). Results: Cardiac baroreflex gain was more than doubled in MA compared to SE (MA: 7.69±7.95, SE: 3.18±1.29, ms/mmHg, P=0.018). However, dCA was similar in the two groups (normalized gain: MA: 1.50±0.56, SE: 1.56±0.42, %CBFV/mmHg, P=0.792). Conclusion: These findings suggest that lifelong exercise improves cardiac baroreflex function, but does not alter dCA. Thus, beneficial effects of exercise training on BP regulation can be achieved in older adults without compromising dynamic regulation of CBF. |
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Authors:
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Vincent Laurens Aengevaeren; Jurgen A H R Claassen; Benjamin D Levine; Rong Zhang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-8 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Radboud University Nijmegen Medical Center. |
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