Document Detail


Cardiac baroreflex function and dynamic cerebral autoregulation in elderly Masters athletes.
MedLine Citation:
PMID:  23139365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebral blood flow (CBF) is stably maintained through the combined effects of blood pressure (BP) regulation and cerebral autoregulation. Previous studies suggest that aerobic exercise training improves cardiac baroreflex function and beneficially affects BP regulation, but may negatively affect cerebral autoregulation. The purpose of this study was to reveal the impact of lifelong exercise on cardiac baroreflex function and dynamic cerebral autoregulation (CA) in older adults. Eleven Masters athletes (MA) (8 men, 3 women; mean age 73 ± 6 yr; aerobic training >15 yr) and 12 healthy sedentary elderly (SE) (7 men, 5 women; mean age 71 ± 6 yr) participated in this study. BP, CBF velocity (CBFV), and heart rate were measured during resting conditions and repeated sit-stand maneuvers to enhance BP variability. Baroreflex gain was assessed using transfer function analysis of spontaneous changes in systolic BP and R-R interval in the low frequency range (0.05-0.15 Hz). Dynamic CA was assessed during sit-stand-induced changes in mean BP and CBFV at 0.05 Hz (10 s sit, 10 s stand). Cardiac baroreflex gain was more than doubled in MA compared with SE (MA, 7.69 ± 7.95; SE, 3.18 ± 1.29 ms/mmHg; P = 0.018). However, dynamic CA was similar in the two groups (normalized gain: MA, 1.50 ± 0.56; SE, 1.56 ± 0.42% CBFV/mmHg; P = 0.792). These findings suggest that lifelong exercise improves cardiac baroreflex function, but does not alter dynamic CA. Thus, beneficial effects of exercise training on BP regulation can be achieved in older adults without compromising dynamic regulation of CBF.
Authors:
Vincent L Aengevaeren; Jurgen A H R Claassen; Benjamin D Levine; Rong Zhang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-08
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  114     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-16     Completed Date:  2013-08-30     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195-202     Citation Subset:  IM    
Affiliation:
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas and Department of Internal Medicine-Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging / physiology*
Athletes*
Baroreflex / physiology*
Blood Pressure / physiology
Brain / blood supply
Cerebrovascular Circulation / physiology*
Cross-Sectional Studies
Exercise / physiology
Female
Heart / physiology*
Homeostasis / physiology*
Humans
Life Style
Male
Physical Endurance / physiology
Regional Blood Flow / physiology
Sedentary Lifestyle

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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