Document Detail

Cardiac autonomic function and cardiovascular response to exercise in patients with chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  22276986     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with impaired exercise tolerance, but it has not been established to what extent cardiac autonomic function impacts on exercise capacity.
OBJECTIVE: To evaluate whether there is an association between airflow limitation and cardiac autonomic function and whether cardiac autonomic function plays a role in exercise intolerance and daily physical activity (PA) in patients with COPD.
METHODS: Univariate and multivariate analyses were performed to evaluate the association between both 6-minute walking test (6MWT) and PA (steps per day) and pulmonary function, cardiac autonomic function (HR at rest, HRR and heart rate variability, HRV) in patients with COPD.
RESULTS: In 154 COPD patients (87 females, mean [SD]: age 62.5 [10.7] years, FEV(1) %predicted (43.0 [19.2]%), mean HR at rest was elevated (86.4 [16.4] beats/min) and HRV was reduced (33.69 [28.96] ms) compared to published control data. There was a significant correlation between FEV(1) and HR at rest (r = -0.32, p < 0.001), between HR at rest and 6MWD (r = -0.26, p = 0.001) and between HR at rest and PA (r = -0.29, p = 0.010). No correlation was found between HRV and 6MWD (r = 0.089, p = 0.262) and PA (r = 0.075, p = 0.322). In multivariate analysis both HR and FEV(1) were independent predictors of exercise capacity in patients with COPD.
CONCLUSIONS: In patients with COPD the degree of airflow limitation is associated with HR at rest. The degree of airflow limitation and cardiac autonomic function, as quantified by HR at rest, are independently associated with exercise capacity in patients with COPD.
Arnoldus J R van Gestel; Malcolm Kohler; Jörg Steier; Urte Sommerwerck; Sebastian Teschler; Erich W Russi; Helmut Teschler
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Publication Detail:
Type:  Journal Article     Date:  2012-01-25
Journal Detail:
Title:  COPD     Volume:  9     ISSN:  1541-2563     ISO Abbreviation:  COPD     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-30     Completed Date:  2013-03-29     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101211769     Medline TA:  COPD     Country:  England    
Other Details:
Languages:  eng     Pagination:  160-5     Citation Subset:  IM    
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MeSH Terms
Activities of Daily Living
Autonomic Agents
Autonomic Nervous System / physiopathology*
Cross-Sectional Studies
Exercise Test
Exercise Tolerance / physiology*
Forced Expiratory Volume
Heart / innervation*
Heart Function Tests
Lung / physiopathology*
Middle Aged
Multivariate Analysis
Pulmonary Disease, Chronic Obstructive / physiopathology*
Pulmonary Ventilation / physiology*
Regression Analysis
Reg. No./Substance:
0/Autonomic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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