Document Detail

Cardiac arrhythmias and sudden unexpected death in epilepsy (SUDEP).
MedLine Citation:
PMID:  22126214     Owner:  NLM     Status:  MEDLINE    
Sudden unexpected death in epilepsy (SUDEP) is a major clinical problem in epilepsy patients in the United States, especially those with chronic, uncontrolled epilepsy. Several pathophysiological events contributing to SUDEP include cardiac arrhythmias, respiratory dysfunction, and dysregulation of systemic or cerebral circulation. There is a significant body of literature suggesting the prominent role of cardiac arrhythmias in the pathogenesis of SUDEP. There is evidence to say that long-standing epilepsy can cause physiological and anatomical autonomic instability resulting in life-threatening arrhythmias. Tachyarrhythmias, bradyarrhythmias, and asystole are commonly seen during ictal, interictal, and postictal phase in epilepsy patients. It is unclear if these rhythm disturbances need attention as some of them may be just benign findings. Evidence regarding prolonged cardiovascular monitoring or the benefit of pacemaker/defibrillator implantation for primary or secondary prevention in epilepsy patients is limited. Awareness regarding pathophysiology, cardiac effects, and management options of SUDEP will become useful in guiding more individualized treatment in the near future. (PACE 2011; 1-8).
Poonam Velagapudi; Mohit Turagam; Thomas Laurence; Abraham Kocheril
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-11-29
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  35     ISSN:  1540-8159     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-06     Completed Date:  2012-07-18     Revised Date:  2012-08-29    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  363-70     Citation Subset:  IM    
Copyright Information:
©2011, The Authors. Journal compilation ©2011 Wiley Periodicals, Inc.
Department of Clinical Cardiac Electrophysiology and Cardiovascular Medicine, University of Illinois, Urbana, IL, USA.
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MeSH Terms
Anticonvulsants / adverse effects,  therapeutic use
Arrhythmias, Cardiac / etiology,  genetics,  mortality*
Autonomic Nervous System / physiopathology
Cerebral Cortex / physiopathology
Channelopathies / drug therapy,  genetics,  physiopathology
Death, Sudden / epidemiology,  etiology*
Epilepsy / drug therapy,  genetics,  mortality*,  physiopathology
Heart Rate / genetics,  physiology
Risk Factors
Reg. No./Substance:
Comment In:
Pacing Clin Electrophysiol. 2012 Jul;35(7):905; author reply 905-6   [PMID:  22553913 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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