| Cardiac arrhythmias and sudden unexpected death in epilepsy (SUDEP). | |
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MedLine Citation:
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PMID: 22126214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sudden unexpected death in epilepsy (SUDEP) is a major clinical problem in epilepsy patients in the United States, especially those with chronic, uncontrolled epilepsy. Several pathophysiological events contributing to SUDEP include cardiac arrhythmias, respiratory dysfunction, and dysregulation of systemic or cerebral circulation. There is a significant body of literature suggesting the prominent role of cardiac arrhythmias in the pathogenesis of SUDEP. There is evidence to say that long-standing epilepsy can cause physiological and anatomical autonomic instability resulting in life-threatening arrhythmias. Tachyarrhythmias, bradyarrhythmias, and asystole are commonly seen during ictal, interictal, and postictal phase in epilepsy patients. It is unclear if these rhythm disturbances need attention as some of them may be just benign findings. Evidence regarding prolonged cardiovascular monitoring or the benefit of pacemaker/defibrillator implantation for primary or secondary prevention in epilepsy patients is limited. Awareness regarding pathophysiology, cardiac effects, and management options of SUDEP will become useful in guiding more individualized treatment in the near future. (PACE 2011; 1-8). |
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Authors:
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Poonam Velagapudi; Mohit Turagam; Thomas Laurence; Abraham Kocheril |
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Publication Detail:
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Type: Journal Article; Review Date: 2011-11-29 |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: 35 ISSN: 1540-8159 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-06 Completed Date: 2012-07-18 Revised Date: 2012-08-29 |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 363-70 Citation Subset: IM |
Copyright Information:
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©2011, The Authors. Journal compilation ©2011 Wiley Periodicals, Inc. |
Affiliation:
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Department of Clinical Cardiac Electrophysiology and Cardiovascular Medicine, University of Illinois, Urbana, IL, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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adverse effects,
therapeutic use Arrhythmias, Cardiac / etiology, genetics, mortality* Autonomic Nervous System / physiopathology Cerebral Cortex / physiopathology Channelopathies / drug therapy, genetics, physiopathology Death, Sudden / epidemiology, etiology* Electrocardiography Epilepsy / drug therapy, genetics, mortality*, physiopathology Female Heart Rate / genetics, physiology Humans Male Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
| Comments/Corrections | |
Comment In:
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Pacing Clin Electrophysiol. 2012 Jul;35(7):905; author reply 905-6
[PMID:
22553913
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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