Document Detail

Cardiac adaptive responses after hypoxia in an experimental model.
MedLine Citation:
PMID:  19939823     Owner:  NLM     Status:  MEDLINE    
The role of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in mediating hypoxic preconditioning under the acute intermittent hypoxic condition (AIH) was investigated in this study. Male Wistar rats were randomly assigned and kept in normoxic conditions, (Nx) or in AIH conditions and subjected to brief cycles hypoxia/reoxygenation. Hearts were isolated, perfused, and subjected to in vitro global ischemia followed by reperfusion. During and at the end of reperfusion, left ventricular developed pressure (LVDP); LV end diastolic pressure (LVEDP); rate pressure product (RPP); peak left ventricular pressure rise (DeltaP/Deltat (max) ) and heart rate (HR) were measured. Hearts subjected to AIH displayed a significant higher LVDP (P < .001), RPP (P < .001), and DeltaP/Deltat ( max) (P < .001). Expression of VEGF and EPO were significantly increased at 3, 8, and 24 hours after AIH. Hypoxic training could provide a new approach to enhance endogenous cardioprotective mechanisms.
Ismaeel Bin-Jaliah; Hania I Ammar; Dimitri P Mikhailidis; Mohammed A Dallak; Fahaid H Al-Hashem; Mohamed A Haidara; Hanaa Z Yassin; Abeer A Bahnasi; Laila A Rashed; Esma R Isenovic
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-24
Journal Detail:
Title:  Angiology     Volume:  61     ISSN:  1940-1574     ISO Abbreviation:  Angiology     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  145-56     Citation Subset:  IM    
Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
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MeSH Terms
Adaptation, Physiological
Anoxia / physiopathology*
Erythropoietin / metabolism,  physiology*
Ischemic Preconditioning, Myocardial*
Myocardial Reperfusion Injury / metabolism,  physiopathology*
Myocytes, Cardiac / metabolism
Rats, Wistar
Vascular Endothelial Growth Factor A / metabolism,  physiology*
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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