| Cardiac adaptive responses after hypoxia in an experimental model. | |
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MedLine Citation:
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PMID: 19939823 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in mediating hypoxic preconditioning under the acute intermittent hypoxic condition (AIH) was investigated in this study. Male Wistar rats were randomly assigned and kept in normoxic conditions, (Nx) or in AIH conditions and subjected to brief cycles hypoxia/reoxygenation. Hearts were isolated, perfused, and subjected to in vitro global ischemia followed by reperfusion. During and at the end of reperfusion, left ventricular developed pressure (LVDP); LV end diastolic pressure (LVEDP); rate pressure product (RPP); peak left ventricular pressure rise (DeltaP/Deltat (max) ) and heart rate (HR) were measured. Hearts subjected to AIH displayed a significant higher LVDP (P < .001), RPP (P < .001), and DeltaP/Deltat ( max) (P < .001). Expression of VEGF and EPO were significantly increased at 3, 8, and 24 hours after AIH. Hypoxic training could provide a new approach to enhance endogenous cardioprotective mechanisms. |
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Authors:
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Ismaeel Bin-Jaliah; Hania I Ammar; Dimitri P Mikhailidis; Mohammed A Dallak; Fahaid H Al-Hashem; Mohamed A Haidara; Hanaa Z Yassin; Abeer A Bahnasi; Laila A Rashed; Esma R Isenovic |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-24 |
Journal Detail:
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Title: Angiology Volume: 61 ISSN: 1940-1574 ISO Abbreviation: Angiology Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-02-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 145-56 Citation Subset: IM |
Affiliation:
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Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Animals Anoxia / physiopathology* Erythropoietin / metabolism, physiology* Immunohistochemistry Ischemic Preconditioning, Myocardial* Male Myocardial Reperfusion Injury / metabolism, physiopathology* Myocytes, Cardiac / metabolism Rats Rats, Wistar Vascular Endothelial Growth Factor A / metabolism, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Vascular Endothelial Growth Factor A; 11096-26-7/Erythropoietin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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