| Cardiac 17O MRI: toward direct quantification of myocardial oxygen consumption. | |
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MedLine Citation:
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PMID: 20512845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new (17)O-labeled blood contrast agent was injected intravenously in control dogs. Electrocardiogram (ECG)-triggered myocardial T(1)rho imaging was performed to obtain spin-locking T(1)rho-weighted myocardial signals for the detection of resultant metabolite H(2) (17)O water in the heart. Bolus and slow injection methods of various doses of the (17)O-labeled and (16)O-labeled agents were carried out in order to evaluate the sensitivity of this method and determine the optimal injection method. Bolus injection provided approximately 1% signal reduction, whereas slow injection with larger amount of agent yielded 11.9 +/- 0.6% signal reduction. Myocardial oxygen consumption rate was determined by a technique to quantify cerebral oxygenation consumption rate previously developed in (17)O brain studies. With either injection method, myocardial oxygen consumption rate at rest was 5.0 - 5.6 micromol/g/min. Therefore, it appears feasible to detect metabolically generated H(2) (17)O water in vivo in the heart, using the (17)O-labeled blood tracer. Myocardial oxygen consumption rate can then be quantified in vivo, which may open new doors for the assessment of myocardial metabolism. |
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Authors:
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Kyle S McCommis; Xiang He; Dana R Abendschein; Pradeep M Gupte; Robert J Gropler; Jie Zheng |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 63 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-23 Revised Date: 2012-02-03 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 1442-7 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media* / administration & dosage Dogs Injections, Intravenous Magnetic Resonance Imaging* / instrumentation, methods Myocardium / metabolism* Oxygen Consumption* Oxygen Isotopes Phantoms, Imaging Pilot Projects Reference Standards |
| Grant Support | |
ID/Acronym/Agency:
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1 R01 HL74019/HL/NHLBI NIH HHS; 1R21 EB009125/EB/NIBIB NIH HHS; P30 DK056341-10/DK/NIDDK NIH HHS; R01 HL074019-04/HL/NHLBI NIH HHS; R21 EB009125-01A1/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Oxygen Isotopes |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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