Document Detail

Cardiac 17O MRI: toward direct quantification of myocardial oxygen consumption.
MedLine Citation:
PMID:  20512845     Owner:  NLM     Status:  MEDLINE    
A new (17)O-labeled blood contrast agent was injected intravenously in control dogs. Electrocardiogram (ECG)-triggered myocardial T(1)rho imaging was performed to obtain spin-locking T(1)rho-weighted myocardial signals for the detection of resultant metabolite H(2) (17)O water in the heart. Bolus and slow injection methods of various doses of the (17)O-labeled and (16)O-labeled agents were carried out in order to evaluate the sensitivity of this method and determine the optimal injection method. Bolus injection provided approximately 1% signal reduction, whereas slow injection with larger amount of agent yielded 11.9 +/- 0.6% signal reduction. Myocardial oxygen consumption rate was determined by a technique to quantify cerebral oxygenation consumption rate previously developed in (17)O brain studies. With either injection method, myocardial oxygen consumption rate at rest was 5.0 - 5.6 micromol/g/min. Therefore, it appears feasible to detect metabolically generated H(2) (17)O water in vivo in the heart, using the (17)O-labeled blood tracer. Myocardial oxygen consumption rate can then be quantified in vivo, which may open new doors for the assessment of myocardial metabolism.
Kyle S McCommis; Xiang He; Dana R Abendschein; Pradeep M Gupte; Robert J Gropler; Jie Zheng
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  63     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-09-23     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1442-7     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
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MeSH Terms
Contrast Media* / administration & dosage
Injections, Intravenous
Magnetic Resonance Imaging* / instrumentation,  methods
Myocardium / metabolism*
Oxygen Consumption*
Oxygen Isotopes
Phantoms, Imaging
Pilot Projects
Reference Standards
Grant Support
1 R01 HL74019/HL/NHLBI NIH HHS; 1R21 EB009125/EB/NIBIB NIH HHS; P30 DK056341/DK/NIDDK NIH HHS; P30 DK056341-10/DK/NIDDK NIH HHS; R01 HL074019/HL/NHLBI NIH HHS; R01 HL074019-04/HL/NHLBI NIH HHS; R21 EB009125/EB/NIBIB NIH HHS; R21 EB009125-01A1/EB/NIBIB NIH HHS
Reg. No./Substance:
0/Contrast Media; 0/Oxygen Isotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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