| Cardiac β(1)-adrenoceptor expression in two stress-induced cardiomyopathy-related deaths. | |
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MedLine Citation:
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PMID: 21159454 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Stress-induced cardiomyopathy (SICM) is characterized by transient systolic dysfunction of the apical and/or midventricular myocardial segments in the absence of obstructive coronary artery disease and is unique in that it can manifest itself after acute emotional stress. Excessive amounts of catecholamines released from sympathetic nerve endings as well as from the adrenal medulla under stressful conditions are considered to produce intracellular Ca(2+) overload and cardiac dysfunction through the β(1)-adrenoceptor signal transduction pathway. We describe the clinical and pathomorphological findings in two stress-induced cardiomyopathy fatal cases. Levels of catecholamines and their metabolites in urine samples were assessed too. Morphological patterns seen in SICM result from the complex interplay between sympathetic innervations, β-receptor density and function and catecholamine sensitivity. |
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Authors:
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Stefano D'Errico; Margherita Neri; Antonio Nieddu; Elena Mazzeo; Irene Riezzo; Emanuela Turillazzi; Vittorio Fineschi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-13 |
Journal Detail:
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Title: Forensic science international Volume: - ISSN: 1872-6283 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902034 Medline TA: Forensic Sci Int Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Forensic Pathology, University of Foggia, Ospedale Colonnello D'Avanzo, Viale degli Aviatori 1, 71100 Foggia, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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