| Carcinosarcoma of the submandibular gland. An autopsy case. | |
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MedLine Citation:
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PMID: 1706554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present a rare case of submandibular gland carcinosarcoma occurring in a 45-year-old male patient. His clinical history revealed that the carcinosarcoma had developed from a carcinoma ex mixed tumor in three years. In spite of repeated resection, intensive chemotherapy and irradiation, the tumor recurred and grew rapidly, and the patient died of hemothorax caused by rupture of a pulmonary metastatic tumor. The fourth recurrent tumor and autopsy specimens showed features of carcinosarcoma consisting of three tumor components, i.e., undifferentiated carcinoma, and chondrosarcomatous and osteosarcomatous growth. The metastatic nodules in both lungs and pulmonary hilar lymph nodes showed the same pattern. Immunohistochemically, the chondrosarcomatous cells were positive for vimentin and S-100 protein, and for epithelial markers such as epithelial membrane antigen (EMA) and cytokeratin (MA-902). Undifferentiated carcinoma cells, on the other hand, were partially positive for muscle actin other than cytokeratin (KL 1). Ultrastructurally, desmosome-like structures were seen in the chondrosarcomatous cells. These findings suggest that the sarcomatous lesions might have originated from epithelial cells. |
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Authors:
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J Suzuki; M Takagi; N Okada; S Hatakeyama; H Yamamoto |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta pathologica japonica Volume: 40 ISSN: 0001-6632 ISO Abbreviation: Acta Pathol. Jpn. Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1991-04-25 Completed Date: 1991-04-25 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372637 Medline TA: Acta Pathol Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 827-31 Citation Subset: IM |
Affiliation:
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Department of Oral Pathology, Faculty of Dentistry, Tokyo Medical and Dental University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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metabolism Adult Autopsy Carcinosarcoma / metabolism, secondary* Humans Immunohistochemistry Keratins / metabolism Male Membrane Glycoproteins / metabolism Microscopy, Electron Mucin-1 Neoplasms, Germ Cell and Embryonal / drug therapy, radiotherapy, surgery S100 Proteins / metabolism Submandibular Gland Neoplasms / metabolism, secondary* Vimentin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Membrane Glycoproteins; 0/Mucin-1; 0/S100 Proteins; 0/Vimentin; 68238-35-7/Keratins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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