Document Detail

Carcinosarcoma of the esophagus. An immunohistochemical and electron microscopic study.
MedLine Citation:
PMID:  2421529     Owner:  NLM     Status:  MEDLINE    
Immunohistochemical and electron microscopic examinations were made of a carcinosarcoma of the esophagus in an 80-year-old man. An immunohistochemical examination showed that sarcomatous spindle cells were vimentin-positive, whereas squamous carcinoma cells were keratin-positive. No coexistence of vimentin and keratin in a single tumor cell was found. Electron microscopically, the sarcomatous spindle cells were characterized by well-developed rough endoplasmic reticulum, abundant intermediate filaments, and the occasional presence of peripheral aggregates of microfilaments. No definite desmosomes were identified among these cells. These results appear to indicate that most of the spindle-shaped tumor cells assume fibroblastic cellular features and synthesize the intermediate filament protein usually expressed in mesenchymal cells, even though such tumor cells could be epithelial in origin.
A Ooi; E Kawahara; Y Okada; Y Mizukami; S Sugawara; Y Noto; H Fujita
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta pathologica japonica     Volume:  36     ISSN:  0001-6632     ISO Abbreviation:  Acta Pathol. Jpn.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-29     Completed Date:  1986-04-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372637     Medline TA:  Acta Pathol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  151-9     Citation Subset:  IM    
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MeSH Terms
Antibodies, Monoclonal
Antigen-Antibody Complex
Carcinosarcoma / pathology*,  ultrastructure
Esophageal Neoplasms / pathology*,  ultrastructure
Keratins / analysis*
Microscopy, Electron
Vimentin / analysis*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigen-Antibody Complex; 0/Vimentin; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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