Document Detail


Carcinosarcoma of the esophagus characterized by myoepithelial and ductal differentiations.
MedLine Citation:
PMID:  12445139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a case of carcinosarcoma of the esophagus characterized by ductal and myoepithelial differentiation. A 61-year-old man was operated on for a polypoid tumor of the distal esophagus. Histologically, this tumor was composed of ductal structures and sarcomatous spindle cells surrounding the ducts at the central area of the tumor. The tumor was also composed of squamous cell and basaloid carcinoma in the periphery. Immunohistochemically, a few spindle cells surrounding the ductal structures showed immunopositivity for alpha-smooth muscle actin and S-100 protein. Electron microscopy revealed that the spindle cells had tonofilament and pinocytic vesicles in the cytoplasm, and basal lamina adjacent to the cytoplasmic membrane. Both of the results strongly supported the suggestion that the spindle cells may be myoepithelial cells. Basaloid carcinoma showed a gradual transition to chondrosarcomatous cells producing the matrix, which had both immunopositivities for S-100 protein and cytokeratin. Therefore, chondrosarcomatous cells may be derived from carcinoma cells. The histogenesis of this tumor may be associated with a totipotent stem cell of esophageal mucosa, which has the potential to differentiate into squamous cells, ductal cells or myoepithelial cells.
Authors:
Masahiko Ohtaka; Toshio Kumasaka; Bunsei Nobukawa; Shu Hirai; Koichi Suda; Yasuhiko Ohno; Ryozo Iwazaki; Yasushi Ikegami; Masaki Fukasawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  52     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-11-26     Completed Date:  2003-06-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  657-63     Citation Subset:  IM    
Affiliation:
Department of Pathology, Juntendo University, School of Medicine, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Actins / analysis
Carcinosarcoma / chemistry,  pathology*,  surgery
Cell Transformation, Neoplastic
Esophageal Neoplasms / chemistry,  pathology*,  surgery
Humans
Male
Middle Aged
Myoepithelioma / chemistry,  pathology*,  surgery
Organelles / ultrastructure
S100 Proteins / analysis
Tumor Markers, Biological / analysis
Chemical
Reg. No./Substance:
0/Actins; 0/S100 Proteins; 0/Tumor Markers, Biological

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