Document Detail

Carcinoma of the hypopharynx and cervical esophagus in young adults.
MedLine Citation:
PMID:  10855572     Owner:  NLM     Status:  MEDLINE    
Squamous cell carcinoma of the hypopharynx and cervical esophagus usually presents in the late-middle-aged and elderly. When diagnosed in young adults, the disease process is often thought to be more aggressive and have a worse long-term outcome. Four hundred ninety patients presented to the Christie Hospital and Manchester Royal Infirmary between 1981 and 1990 with squamous cell carcinoma of the hypopharynx and cervical esophagus. Of this group, 24 patients (5%) received their diagnosis before the age of 45. A comparison is made with a control group of 156 (32%) patients who presented between the ages of 60 and 69 years. Analysis of tumor and nodal staging at presentation demonstrates no statistically significant difference between the 2 age groups. There is a higher incidence of a combination of smoking and alcohol abuse in the older age group, but it is of no statistical significance. There is no difference in 5-year survival results between the 2 groups. We conclude that patients with squamous cell carcinoma of the hypopharynx and cervical esophagus who receive their diagnosis under the age of 45 show no difference in tumor stage or long-term outcome when compared with a control group encompassing the mean age of presentation.
P R Axon; R Simo; N Fergie; R H Temple; W T Farrington
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  109     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-06-26     Completed Date:  2000-06-26     Revised Date:  2006-05-15    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  590-3     Citation Subset:  AIM; IM    
Department of Otolaryngology-Head and Neck Surgery, Manchester Royal Infirmary, England.
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MeSH Terms
Age Factors
Carcinoma, Squamous Cell / diagnosis*,  mortality,  pathology,  therapy
Combined Modality Therapy
Esophageal Neoplasms / diagnosis*,  mortality,  pathology,  therapy
Hypopharyngeal Neoplasms / diagnosis*,  mortality,  pathology,  therapy
Middle Aged
Neoplasm Staging
Risk Factors
Survival Rate

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