Document Detail

Carcinoma arising within an anal gland.
MedLine Citation:
PMID:  22707467     Owner:  NLM     Status:  MEDLINE    
Anal gland carcinoma (AGC) is rare, and its innocuous presentation and developing immunohistochemical profile make the diagnosis of it challenging. Predominant presenting symptoms include anal pain, rectal bleeding and the presence of a perianal mass in advanced stages of the disease. Histological profile commonly reveals an intramural adenocarcinoma with normal unaffected overlying anorectal mucosa. Immunohistochemical analysis shows positive staining for cytokeratin (CK) 7 and negative staining for CK20. MUC5AC expression with CK5/6 and p53 negativity has been reported. The authors report a case of a 68-year-old woman with a rapidly advancing AGC and review the current literature with respect to diagnosis and current consensus on therapeutic management.
M A Zeiton; B C Knight; Y N Khaled; R Green; N Mapstone; K Riyad
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-02-15
Journal Detail:
Title:  BMJ case reports     Volume:  2011     ISSN:  1757-790X     ISO Abbreviation:  BMJ Case Rep     Publication Date:  2011  
Date Detail:
Created Date:  2012-06-18     Completed Date:  2013-02-19     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101526291     Medline TA:  BMJ Case Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Department of Surgery, Royal Blackburn Hospital, Blackburn, Lancashire, UK.
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MeSH Terms
Anal Canal*
Anus Neoplasms / pathology*
Carcinoma / pathology*

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