| Carcinoma arising within an anal gland. | |
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MedLine Citation:
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PMID: 22707467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anal gland carcinoma (AGC) is rare, and its innocuous presentation and developing immunohistochemical profile make the diagnosis of it challenging. Predominant presenting symptoms include anal pain, rectal bleeding and the presence of a perianal mass in advanced stages of the disease. Histological profile commonly reveals an intramural adenocarcinoma with normal unaffected overlying anorectal mucosa. Immunohistochemical analysis shows positive staining for cytokeratin (CK) 7 and negative staining for CK20. MUC5AC expression with CK5/6 and p53 negativity has been reported. The authors report a case of a 68-year-old woman with a rapidly advancing AGC and review the current literature with respect to diagnosis and current consensus on therapeutic management. |
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Authors:
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M A Zeiton; B C Knight; Y N Khaled; R Green; N Mapstone; K Riyad |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2011-02-15 |
Journal Detail:
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Title: BMJ case reports Volume: 2011 ISSN: 1757-790X ISO Abbreviation: BMJ Case Rep Publication Date: 2011 |
Date Detail:
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Created Date: 2012-06-18 Completed Date: 2013-02-19 Revised Date: 2013-04-12 |
Medline Journal Info:
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Nlm Unique ID: 101526291 Medline TA: BMJ Case Rep Country: England |
Other Details:
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Languages: eng Pagination: - Citation Subset: IM |
Affiliation:
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Department of Surgery, Royal Blackburn Hospital, Blackburn, Lancashire, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anal Canal* Anus Neoplasms / pathology* Carcinoma / pathology* Female Humans |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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