Document Detail


Carcinoids and endocrine cell micronests of the minor and major duodenal papillae. Their incidence and characteristics.
MedLine Citation:
PMID:  1525756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There have been no reports about the incidence and characteristics of carcinoids and endocrine cell micronests (ECM) of the minor and major duodenal papillae. METHODS AND RESULTS: The minor and major duodenal papillae of 78 consecutive autopsy and 117 surgical specimens were examined histologically using mirror-image paraffin-embedded tissue samples. ECM were found frequently in these areas in hematoxylin and eosin-stained sections, and their aggregation patterns were classified into four types: nodular type (Type 1, 2 of 167 in the minor papilla and 1 of 145 in the major papilla), scattered type (Type 2, 39 of 167 and 6 of 145), orifice type (Type 3, 7 of 167 and 0 of 145), and islet-like type (Type 4, 14 of 145 and 0 of 145, respectively). Criteria of neoplastic or nonneoplastic ECM were defined tentatively by histologic and immunohistochemical analyses of the ECM. Type 4 was regarded to be atrophic or regenerating islets of Langerhans. Distinct carcinoids (Type 1), neoplastic ECM (39% of all Type 2 and 3), and nonneoplastic ECM (61% of all Type 2 and 3) were found in 1.2%, 9.0%, and 16.2% of 167 samples of the minor papilla and 0.7%, 1.4%, and 2.8% of 145 specimens of the major papilla, respectively. The endocrine cells composing the carcinoids and the ECM usually were immunoreactive for somatostatin and/or pancreatic polypeptide (PP). They were negative for S-100 beta. CONCLUSION: In duodenal papillae, especially in the minor duodenal papilla, carcinoids and ECM seem to occur more frequently than generally thought, and predominantly consist of somatostatin and/or PP containing cells.
Authors:
Y Noda; H Watanabe; M Iwafuchi; K Furuta; N Ishihara; M Satoh; Y Ajioka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer     Volume:  70     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-10-22     Completed Date:  1992-10-22     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1825-33     Citation Subset:  AIM; IM    
Affiliation:
First Department of Pathology, Niigata University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Ampulla of Vater / cytology*,  ultrastructure
Carcinoid Tumor / pathology*
Child
Child, Preschool
Common Bile Duct Neoplasms / pathology*
Endocrine Glands / cytology*,  ultrastructure
Female
Humans
Immunohistochemistry
Infant
Male
Middle Aged
Pancreatic Ducts / cytology*,  ultrastructure
Pancreatic Neoplasms / pathology*

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