| Carcinoid tumor and the nephrotic syndrome: a novel association between neoplasia and glomerular disease. | |
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MedLine Citation:
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PMID: 8578361 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Various malignancies are associated with the paraneoplastic evolution of the nephrotic syndrome. Renal biopsy in these instances frequently shows membranous glomerulonephritis. We describe a patient who had metastatic bronchial carcinoid tumor with development of microscopic hematuria and subsequent nephrotic syndrome in conjunction with another paraneoplastic process, a malignancy-related neuropathy. A decline in actual glomerular filtration rate led to percutaneous renal biopsy, which revealed fine holes in the glomerular basement membrane and focal capillary corrugation. Electron microscopy showed numerous small subepithelial dense deposits and fusion of foot processes, confirming the diagnosis of stage I membranous nephropathy. We believe this is the first published case of true carcinoid tumor associated with the nephrotic syndrome and a specific paraneoplastic glomerular lesion. Carcinoid tumor should be considered in the spectrum of malignancies associated with paraneoplastic development of the nephrotic syndrome. |
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Authors:
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B N Becker; G Goldin; R Santos; A Glick; D H Johnson; J A Breyer; G S Schulman |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Southern medical journal Volume: 89 ISSN: 0038-4348 ISO Abbreviation: South. Med. J. Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-03-14 Completed Date: 1996-03-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 240-2 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Vanderbilt University Medical Center, Nashville, Tenn 37232-2372, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Basement Membrane
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pathology Bronchial Neoplasms / complications* Capillaries / pathology Carcinoid Tumor / complications* Female Glomerular Filtration Rate Glomerulonephritis, Membranous / etiology* Humans Kidney Glomerulus / pathology Microscopy, Electron Middle Aged Nephrotic Syndrome / etiology* Paraneoplastic Syndromes / etiology* Peripheral Nervous System Diseases / etiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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