Document Detail

Carcinogenicity of methylated nitrosopiperazines in rats and hamsters.
MedLine Citation:
PMID:  6883638     Owner:  NLM     Status:  MEDLINE    
A comparison has been made of the carcinogenic activities of dinitroso-2,6-dimethylpiperazine (Me2DNP) and nitroso-3-4,5-trimethylpiperazine (Me3NP) in F344 rats and Syrian golden hamsters. The compounds were administered in drinking water to the rats and by gavage to the hamsters, at similar dose rates. As measured by the increased rate of mortality from tumors induced, Me2DNP was a more potent carcinogen in rats than Me3NP; Me2DNP induced mainly esophageal tumors, while Me3NP induced tumors of the nasal cavity, but no esophageal tumors. In contrast, in Syrian hamsters, by the same criterion, Me3NP was at least as potent as Me2DNP. Me3NP was more potent in hamsters than Me2DNP as measured by the number and multiplicity of tumors induced. The most numerous tumors induced by both compounds in hamsters were papillomas of the forestomach, but in addition Me3NP induced a high incidence of lung tumors. A small number of hamsters treated with either compound had liver angiosarcomas. Two hamsters given Me3NP had papillomas of the esophagus, a highly unusual tumor in Syrian hamsters.
W Lijinsky; G M Knutsen; M D Reuber
Related Documents :
6939938 - Carcinogenicity of n-methyl-n-nitrosourea and n-ethyl-n-nitrosourea when applied to a l...
22194218 - Dm-1, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenola...
21309258 - Endometrioid carcinoma of the endometrium: pathologic and molecular features.
4634738 - Undifferentiated intraperitoneal tumors induced by human adenovirus type 12 in hamsters.
2339598 - Elastosis in meningioma.
24692008 - Microrna-203 inhibits the progression of esophageal squamous cell carcinoma with restor...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Carcinogenesis     Volume:  4     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1165-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carcinogens / toxicity*
Neoplasms, Experimental / chemically induced*
Nitrosamines / toxicity*
Rats, Inbred F344
Structure-Activity Relationship
Grant Support
Reg. No./Substance:
0/Carcinogens; 0/Nitrosamines; 55380-34-2/2,6-dimethyldinitrosopiperazine; 77267-12-0/1-nitroso-3,4,5-trimethylpiperazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Occupational nitrosamine exposure. 1. Rubber and tyre industry.
Next Document:  On the metabolism of quinoline and isoquinoline: possible molecular basis for differences in biologi...