Document Detail


Carcinogenicity of methylated nitrosopiperazines in rats and hamsters.
MedLine Citation:
PMID:  6883638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A comparison has been made of the carcinogenic activities of dinitroso-2,6-dimethylpiperazine (Me2DNP) and nitroso-3-4,5-trimethylpiperazine (Me3NP) in F344 rats and Syrian golden hamsters. The compounds were administered in drinking water to the rats and by gavage to the hamsters, at similar dose rates. As measured by the increased rate of mortality from tumors induced, Me2DNP was a more potent carcinogen in rats than Me3NP; Me2DNP induced mainly esophageal tumors, while Me3NP induced tumors of the nasal cavity, but no esophageal tumors. In contrast, in Syrian hamsters, by the same criterion, Me3NP was at least as potent as Me2DNP. Me3NP was more potent in hamsters than Me2DNP as measured by the number and multiplicity of tumors induced. The most numerous tumors induced by both compounds in hamsters were papillomas of the forestomach, but in addition Me3NP induced a high incidence of lung tumors. A small number of hamsters treated with either compound had liver angiosarcomas. Two hamsters given Me3NP had papillomas of the esophagus, a highly unusual tumor in Syrian hamsters.
Authors:
W Lijinsky; G M Knutsen; M D Reuber
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Carcinogenesis     Volume:  4     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1165-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogens / toxicity*
Cricetinae
Female
Male
Mesocricetus
Neoplasms, Experimental / chemically induced*
Nitrosamines / toxicity*
Rats
Rats, Inbred F344
Structure-Activity Relationship
Grant Support
ID/Acronym/Agency:
N01-CO-23909/CO/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Nitrosamines; 55380-34-2/2,6-dimethyldinitrosopiperazine; 77267-12-0/1-nitroso-3,4,5-trimethylpiperazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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