Document Detail


Carcinogenicity of lifelong administration of capsaicin of hot pepper in mice.
MedLine Citation:
PMID:  1627743     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Capsaicin was administered in a semisynthetic powdered diet at 0.03125% level for the lifespan of Swiss mice starting from 6 weeks of age. As a result of C treatment, tumors of the cecum were induced in 22% of females and 14% of males, whereas the corresponding tumor incidences in untreated female and male controls were both 8%. Histopathologically, the tumors were classified as benign polypoid adenomas. Capsaicin is the main pungent principle of hot pepper, which is consumed in high quantities by humans worldwide. The capsaicin content of some chili varieties ranges up to 0.53%.
Authors:
B Toth; P Gannett
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  6     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    1992 Jan-Feb
Date Detail:
Created Date:  1992-08-20     Completed Date:  1992-08-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  59-63     Citation Subset:  IM    
Affiliation:
Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha 68198-6805.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Capsaicin / administration & dosage,  toxicity*
Cecal Neoplasms / chemically induced*
Condiments / toxicity*
Female
Intestinal Polyps / chemically induced*
Longevity / drug effects
Male
Mice
Neoplasms, Experimental / chemically induced*
Sex Factors
Grant Support
ID/Acronym/Agency:
CA40989/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
404-86-4/Capsaicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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