Document Detail


Carcinogenic risk assessment of complex mixtures.
MedLine Citation:
PMID:  2683227     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although procedures for assessing the carcinogenic risks associated with exposure to individual chemicals are relatively well developed, risk assessment methods for mixtures of chemicals are still in the developmental stage. In this paper, we examine the difficulties in assessing the risks of exposure to complex mixtures, with special reference to the potential for synergistic effects among the components of the mixture. Statistical models for describing the joint action of multiple exposures are reviewed, and their implications for low-dose risk assessment are examined. The potential use of pharmacokinetic models to describe the metabolism of mixtures is also considered. Application of these results in regulating mixtures of carcinogenic substances is illustrated using examples involving multiple contaminants in drinking water and polycyclic aromatic hydrocarbons produced from combustion sources.
Authors:
D Krewski; T Thorslund; J Withey
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Toxicology and industrial health     Volume:  5     ISSN:  0748-2337     ISO Abbreviation:  Toxicol Ind Health     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-12-05     Completed Date:  1989-12-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8602702     Medline TA:  Toxicol Ind Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  851-67     Citation Subset:  IM    
Affiliation:
Health and Welfare Canada, Ottawa.
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MeSH Terms
Descriptor/Qualifier:
Carcinogenicity Tests
Carcinogens, Environmental* / administration & dosage
Drug Interactions
Humans
Models, Theoretical
Risk
Chemical
Reg. No./Substance:
0/Carcinogens, Environmental

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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