| Carcinogenic activity of cigarette smoke gas phase and its modulation by beta-carotene and N-acetylcysteine. | |
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MedLine Citation:
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PMID: 15564316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Male strain A/J mice were exposed for six hours a day, five days a week for six months to either full tobacco smoke or to tobacco smoke drawn through a HEPA filter that removed more than 99% of particulate matter. After another four months in air, the animals were sacrificed and lung tumors were counted for calculation of multiplicities and incidences. Analysis of the chamber atmospheres showed that in the filtered smoke the concentrations of polycyclic aromatic hydrocarbons and tobacco smoke specific nitrosamines were reduced to from below 18% to even nondetectable levels of the original values measured in the unfiltered smoke. Aldehydes and other volatile organic compounds such as 1,3-butadiene, benzene, or acrolein were reduced to about 50 to 90% of the concentrations found in unfiltered smoke. Some potentially carcinogenic metals reached levels in filtered smoke ranging from 77% to less than 1% found in full smoke. The mice exposed to the filtered smoke atmosphere had practically identical lung tumor multiplicities and incidence as had the animals exposed to full smoke, significantly higher than in air exposed controls. Diets containing 0.5% beta-carotene or 0.4% N-acetylcysteine afforded some chemoprevention. It was tentatively concluded that 1,3-butadiene might be an important contributor to lung tumorigenesis in this mouse model of tobacco smoke carcinogenesis. |
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Authors:
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Hanspeter Witschi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. Date: 2004-11-24 |
Journal Detail:
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Title: Toxicological sciences : an official journal of the Society of Toxicology Volume: 84 ISSN: 1096-6080 ISO Abbreviation: Toxicol. Sci. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-02-10 Completed Date: 2005-06-08 Revised Date: 2010-09-17 |
Medline Journal Info:
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Nlm Unique ID: 9805461 Medline TA: Toxicol Sci Country: United States |
Other Details:
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Languages: eng Pagination: 81-7 Citation Subset: IM |
Affiliation:
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Center for Health and the Environment, University of California, Davis, One Shields Avenue, Davis, California 95616, USA. hrwitschi@ucdavis.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcysteine
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pharmacology* Animals Atmosphere Exposure Chambers Carcinogens / antagonists & inhibitors*, toxicity* Free Radical Scavengers / pharmacology* Lung Neoplasms / chemically induced, pathology Male Metals / analysis, toxicity Mice Nitrosamines / toxicity Polycyclic Hydrocarbons, Aromatic / analysis, toxicity Smoke Tobacco / toxicity* beta Carotene / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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CA96217/CA/NCI NIH HHS; ES05707/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Free Radical Scavengers; 0/Metals; 0/Nitrosamines; 0/Polycyclic Hydrocarbons, Aromatic; 0/Smoke; 616-91-1/Acetylcysteine; 7235-40-7/beta Carotene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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