Document Detail


Carcinogenesis driven by bone marrow-derived stem cells.
MedLine Citation:
PMID:  16627964     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The overall mechanism of bone marrow-derived stem cell (BMDC) trans-differentiation seems to be simple: BMDCs trans-differentiate as referred to the blueprint, which is given by the tissue itself. Thereby, the blueprint can be the local tissue micro-environment (defined by the tissue-specific cytokine, chemokine, adhesion molecule pattern, etc.), it can be a single cell (cell fusion), or it can be a combination of both. In fact stem cell trans-differentiation is a complex not yet fully understood process. In between the start- and stop-points of transdifferentiation several gene reprogramming steps have to occur in a sequential step-by-step manner, for which a defined set of instructions is a prerequisite to ensure an accurate transdifferentiation. However, a recent study indicated that the ability of BMDCs - to adopt tissue function by reading its blueprint - seems to be a double-edged sword since BMDCs that have received a faulty blueprint, provided by chronically inflamed tissue, trans-differentiated into a neoplastic phenoytpe. Here, we review the importance of an accurate blueprint for BMDC trans-differentiation and discuss a model showing that BMDCs might contribute to overall tumor development due to recruitment to tumor tissue.
Authors:
Thomas Dittmar; Jeanette Seidel; Kurt S Zaenker; Bernd Niggemann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Contributions to microbiology     Volume:  13     ISSN:  1420-9519     ISO Abbreviation:  Contrib Microbiol     Publication Date:  2006  
Date Detail:
Created Date:  2006-04-21     Completed Date:  2006-07-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9815689     Medline TA:  Contrib Microbiol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  156-69     Citation Subset:  IM    
Affiliation:
Institute of Immunology, University of Witten/Herdecke, Witten, Germany. thomasd@uni-wh.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / physiology*
Cell Transformation, Neoplastic / pathology*
Hematopoietic Stem Cells / cytology
Humans
Hybrid Cells / cytology
Mesenchymal Stem Cells / cytology
Neoplasms / pathology*
Neoplastic Stem Cells / pathology
Stem Cells / cytology*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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