| Carcinogenesis driven by bone marrow-derived stem cells. | |
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MedLine Citation:
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PMID: 16627964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The overall mechanism of bone marrow-derived stem cell (BMDC) trans-differentiation seems to be simple: BMDCs trans-differentiate as referred to the blueprint, which is given by the tissue itself. Thereby, the blueprint can be the local tissue micro-environment (defined by the tissue-specific cytokine, chemokine, adhesion molecule pattern, etc.), it can be a single cell (cell fusion), or it can be a combination of both. In fact stem cell trans-differentiation is a complex not yet fully understood process. In between the start- and stop-points of transdifferentiation several gene reprogramming steps have to occur in a sequential step-by-step manner, for which a defined set of instructions is a prerequisite to ensure an accurate transdifferentiation. However, a recent study indicated that the ability of BMDCs - to adopt tissue function by reading its blueprint - seems to be a double-edged sword since BMDCs that have received a faulty blueprint, provided by chronically inflamed tissue, trans-differentiated into a neoplastic phenoytpe. Here, we review the importance of an accurate blueprint for BMDC trans-differentiation and discuss a model showing that BMDCs might contribute to overall tumor development due to recruitment to tumor tissue. |
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Authors:
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Thomas Dittmar; Jeanette Seidel; Kurt S Zaenker; Bernd Niggemann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Contributions to microbiology Volume: 13 ISSN: 1420-9519 ISO Abbreviation: Contrib Microbiol Publication Date: 2006 |
Date Detail:
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Created Date: 2006-04-21 Completed Date: 2006-07-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9815689 Medline TA: Contrib Microbiol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 156-69 Citation Subset: IM |
Affiliation:
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Institute of Immunology, University of Witten/Herdecke, Witten, Germany. thomasd@uni-wh.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / physiology* Cell Transformation, Neoplastic / pathology* Hematopoietic Stem Cells / cytology Humans Hybrid Cells / cytology Mesenchymal Stem Cells / cytology Neoplasms / pathology* Neoplastic Stem Cells / pathology Stem Cells / cytology*, pathology |
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