| Carcinoembryonic antigen assay of ascites and detection of malignancy. | |
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MedLine Citation:
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PMID: 646247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Levels of carcinoembryonic antigen (CEA) activity were measured in 105 unselected samples of ascitic fluid submitted for routine cytologic analysis to ascertain whether this assay was useful in the detection of malignancy. The highest CEA level found in the 70 specimens of "benign" ascites was 10 ng/ml. Using values greater than 10 ng/ml as indicating a cancerous effusion, CEA assay successfully detected 14 of the 29 malignant ascites studied. Cytology, on the other hand, detected only 12 of these fluids. Combining the two methods increased the yield to 20. The CEA assay alone thus detected more than one fourth of these malignant fluids. The assay was particularly useful in detecting malignant transudates, nearly half of which had elevated CEA levels despite negative cytologic findings. The CEA assay of ascites thus showed promise as an adjunct to cytology in the detection of malignant ascites when used as part of a complete clinical and laboratory assessment. |
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Authors:
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M S Loewenstein; R A Rittgers; A E Feinerman; H Z Kupchik; B R Marcel; R S Koff; N Zamcheck |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of internal medicine Volume: 88 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1978 May |
Date Detail:
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Created Date: 1978-06-28 Completed Date: 1978-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 635-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ascitic Fluid
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immunology* Breast Neoplasms / immunology Carcinoembryonic Antigen / analysis* Female Gastrointestinal Neoplasms / immunology Humans Neoplasms / diagnosis*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Carcinoembryonic Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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