Document Detail


Carcinoembryonic antigen (CEA) in serum and bile of colorectal cancer patients with or without detectable liver metastases.
MedLine Citation:
PMID:  8067714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been suggested that bile CEA levels could represent a sensitive index for the detection of occult liver metastases in colorectal cancer (CRC) patients. We measured serum and gallbladder bile CEA concentrations in a control group, in a group of patients with benign disease of the biliary tree, and in patients with CRC at different stages. Neoplastic patients without evidence of liver metastases at the time of laparotomy, but with elevated biliary CEA levels, were selected for a follow-up study. Our results indicate that (a) bile CEA levels are falsely increased in several benign biliary diseases; (b) CRC patients with detectable liver metastases have elevated biliary CEA levels; (c) high biliary CEA levels do not represent a predictive parameter for the presence of occult liver metastases in CRC patients.
Authors:
M Paganuzzi; M Onetto; M de Paoli; M Castagnola; L de Salvo; D Civalleri; C E Grossi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  14     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1994 May-Jun
Date Detail:
Created Date:  1994-09-22     Completed Date:  1994-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  1409-12     Citation Subset:  IM    
Affiliation:
Clinical Pathology Division, National Institute for Cancer Research, Genoa, Italy.
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MeSH Terms
Descriptor/Qualifier:
Bile / chemistry*
Carcinoembryonic Antigen / analysis*,  blood
Cholecystitis / metabolism
Cholelithiasis / metabolism
Colorectal Neoplasms / chemistry*
False Positive Reactions
Follow-Up Studies
Humans
Liver Neoplasms / secondary*
Chemical
Reg. No./Substance:
0/Carcinoembryonic Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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