| Carboxypeptidase G2 rescue in a 79 year-old patient with cranial lymphoma after high-dose methotrexate induced acute renal failure. | |
| | |
MedLine Citation:
|
PMID: 10609804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A 79 year-old female patient presented with immunoblastic B-cell lymphoma of the ethmoidal sinuses and destruction of the anterior cranial fossa. After 3 cycles of high-dose methorexate (HD-MTX) MTX serum level remained elevated and creatinine serum levels raised. The patient received Carboxypeptidase G2 (CPG2) intravenously. Within one hour the MTX serum level decreased to <1 micromol/l as determined by high pressure liquid chromatography (HPLC). The patient recovered without significant toxicity and attained a long lasting ongoing (>14 months) complete remission. In this case we were able to demonstrate that rescue from HD-MT nephrotoxicity by CPG2 is also safe and effective in patients with advanced age with impaired renal function. With the help of CPG2, sufficient and potentially curative therapy with HD-MTX may also be provided to patients with a high risk of renal failure. |
| | |
Authors:
|
A Krackhardt; S Schwartz; A Korfel; E Thiel |
Related Documents
:
|
21257724 - Evaluation of the respective influence of thyroid hormones and thyrotropin on blood coa... 16311264 - Haemodialysis vascular access problems in canada: results from the dialysis outcomes an... 2545994 - Increased serum levels of endopeptidase 24.11 ('enkephalinase') in patients with end-st... 21530164 - A voice acoustic analysis of thyroid adenoma patients after a unilateral thyroid lobect... 1573584 - Oral hypoglycaemic agents: the first thirty years. 2788474 - Rigid endoscopy under general anaesthesia is safe for chronic injection sclerotherapy. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Leukemia & lymphoma Volume: 35 ISSN: 1042-8194 ISO Abbreviation: Leuk. Lymphoma Publication Date: 1999 Nov |
Date Detail:
|
Created Date: 2000-02-14 Completed Date: 2000-02-14 Revised Date: 2006-04-24 |
Medline Journal Info:
|
Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 631-5 Citation Subset: IM |
Affiliation:
|
Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Freie Universität Berlin, Universitäsklinikum Benjamin Franklin, Germany. aljoscha@zedat.fu-berlin.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Antimetabolites, Antineoplastic / administration & dosage, adverse effects* Antineoplastic Combined Chemotherapy Protocols / therapeutic use Bacterial Proteins / therapeutic use* Carmustine / administration & dosage Combined Modality Therapy Cyclophosphamide / administration & dosage Dexamethasone / administration & dosage Diuretics / therapeutic use Doxorubicin / administration & dosage Ethmoid Sinus* Female Fluid Therapy Folic Acid / metabolism Furosemide / therapeutic use Humans Kidney Failure, Acute / chemically induced*, drug therapy, therapy Leucovorin / administration & dosage Lymphoma, B-Cell / drug therapy* Lymphoma, Large-Cell, Immunoblastic / drug therapy*, pathology Methotrexate / administration & dosage, adverse effects*, antagonists & inhibitors, metabolism Paranasal Sinus Neoplasms / drug therapy* Prednisone / administration & dosage Procarbazine / administration & dosage Remission Induction Vincristine / administration & dosage gamma-Glutamyl Hydrolase / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Antimetabolites, Antineoplastic; 0/Bacterial Proteins; 0/CHOP protocol; 0/Diuretics; 154-93-8/Carmustine; 23214-92-8/Doxorubicin; 50-02-2/Dexamethasone; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 54-31-9/Furosemide; 57-22-7/Vincristine; 58-05-9/Leucovorin; 59-05-2/Methotrexate; 59-30-3/Folic Acid; 671-16-9/Procarbazine; EC 3.4.19.9/gamma-Glutamyl Hydrolase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acute minimally differentiated myeloid leukemia (M0) with inv(3)(q21q26).
Next Document: HTLV-I induced intestinal lymphoma.