Document Detail

Carboxymethyl chitin-glucan enriched diet exhibits protective effects against oxidative DNA damage induced in freshly isolated rat cells.
MedLine Citation:
PMID:  17013539     Owner:  NLM     Status:  MEDLINE    
The connection between dietary intake of carboxymethyl chitin-glucan (CM-CG, approximately 200 mg/kg body weight, during 21 days) and the response of freshly isolated rat cells to genotoxic treatment with a combination of photosensitizer Methylene Blue and visible light (MB+VL) was evaluated in presented study. Blood lymphocytes, testicular cells, and hepatocytes were isolated from rats fed by a standard or CM-CG enriched diet and in ex vivo conditions challenged with oxidative agent. Induced DNA damage was assessed using a modified comet assay. When added to the diet, CM-CG itself did not induce any negative effect on the health condition of animals or on level of DNA breaks in rat cells. Moreover, the cells isolated from CM-CG fed animals were more resistant to oxidative stress induced by visible light-excited Methylene Blue. In conclusion, we have demonstrated that carboxymethyl chitin-glucan represents a natural fungal polysaccharide that is able to exert antimutagenic properties upon application in diet.
M Lazarová; J Lábaj; G Kogan; D Slamenová
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neoplasma     Volume:  53     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-02     Completed Date:  2007-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  434-9     Citation Subset:  IM    
Cancer Research Institute, Slovak Academy of Sciences, 83391 Bratislava, Slovak Republic.
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MeSH Terms
Antimutagenic Agents / administration & dosage*
Cells, Cultured
Chitin / administration & dosage,  analogs & derivatives*
Comet Assay
DNA Damage / drug effects*
Glucans / administration & dosage*
Methylene Blue / toxicity
Oxidants / toxicity
Oxidative Stress / drug effects*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Antimutagenic Agents; 0/Glucans; 0/Oxidants; 0/carboxymethyl-chitin-glucan; 1398-61-4/Chitin; 61-73-4/Methylene Blue

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