| Carboxylester lipase gene polymorphism as a risk of alcohol-induced pancreatitis. | |
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MedLine Citation:
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PMID: 15841033 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Alcohol abuse causes pancreatic damage in humans. However, only 5% of alcoholic patients have a clinical manifestation of pancreatitis, and the genetic predisposition of alcohol-associated pancreatitis remains elusive. Nonoxidative metabolites of ethanol, fatty acid ethyl esters (FAEEs), might play an important role in pancreatic damage. Carboxylester lipase (CEL) has been known to catalyze FAEE synthesis from fatty acids and ethanol. METHODS: The variable number of tandem repeat (VNTR) polymorphism in the coding region of the CEL gene was studied in patients with alcoholic pancreatitis (n = 100), in alcoholics without pancreatitis (n = 52), in patients with nonalcoholic pancreatitis (n = 50), in hyperlipidemia patients (n = 96), and control subjects (n = 435). RESULTS: The frequency of the NN-type (wild-type) gene was significantly decreased in patients with alcoholic pancreatitis than in other groups. The frequency of subjects who had the L allele in patients with alcoholic pancreatitis was significantly higher than in other groups. The distribution of the CEL gene polymorphism was not different among the control subjects, alcoholics without pancreatitis, patients with nonalcoholic pancreatitis, and patients with hyperlipidemia. CONCLUSIONS: The CEL gene polymorphism, especially an increase in the frequency of the L allele, was found to be associated with alcohol-induced pancreatitis. |
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Authors:
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Kyoko Miyasaka; Minoru Ohta; Saeko Takano; Hiroshi Hayashi; Susumu Higuchi; Katsuya Maruyama; Yusuke Tando; Teruo Nakamura; Yutaka Takata; Akihiro Funakoshi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pancreas Volume: 30 ISSN: 1536-4828 ISO Abbreviation: Pancreas Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-20 Completed Date: 2006-03-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: United States |
Other Details:
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Languages: eng Pagination: e87-91 Citation Subset: IM |
Affiliation:
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Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. miyasaka@tmig.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aldehyde Dehydrogenase / genetics Alleles Carboxylesterase / genetics* Female Genetic Predisposition to Disease / epidemiology Genotype Humans Hyperlipidemias / epidemiology, genetics Male Middle Aged Pancreatitis / epidemiology, genetics Pancreatitis, Alcoholic / epidemiology*, genetics* Polymorphism, Genetic* Risk Factors |
| Chemical | |
Reg. No./Substance:
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EC 1.2.1.3/ALDH2 protein, human; EC 1.2.1.3/Aldehyde Dehydrogenase; EC 3.1.1.1/Carboxylesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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