| Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells. | |
| | |
MedLine Citation:
|
PMID: 22200884 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Serine/threonine protein kinase B (PKB/Akt) is involved in cell survival and growth. Carboxyl-terminal modulator protein (CTMP), a novel Akt binding partner, prevents Akt activation at the plasma membrane in response to various stimuli, and thus possesses a tumor suppressor-like function. In a previous study, we have demonstrated that CTMP inhibits tumor progression by facilitating apoptosis in a mouse lung cancer model. However, the precise mechanism of CTMP-induced apoptosis remains to be elucidated. The present study was performed to examine the role of CTMP in mitochondrial-mediated apoptosis and regulation of mitochondrial function in human lung carcinoma cells. Our results showed that CTMP altered mitochondrial morphology and caused the release of cytochrome c by inhibiting OPA1 expression. Additionally, CTMP facilitated mitochondrial-mediated apoptosis by inhibiting heat-shock protein 27 and preventing cytochrome c interaction with Apaf-1. Our data suggest that CTMP may therefore play a critical role in mitochondrial-mediated apoptosis in lung cancer cells. |
| | |
Authors:
|
Soon-Kyung Hwang; Arash Minai-Tehrani; Kyeong-Nam Yu; Seung-Hee Chang; Ji-Eun Kim; Kee-Ho Lee; Jongsun Park; George R Beck; Myung-Haing Cho |
Related Documents
:
|
17303574 - Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of ... 9719464 - Induction of p21 during ceramide-mediated apoptosis in human hepatocarcinoma cells. 21783844 - Protective activity of 30kda phytoglycoprotein from glucose/glucose oxidase-induced cel... 10964614 - Ceramide initiates nfkappab-mediated caspase activation in neuronal apoptosis. 19653144 - 6-hydroxycleroda-3,13-dien-15,16-olide protects neuronal cells from lipopolysaccharide-... 20300584 - Pretreatment with cry1ac protoxin modulates the immune response, and increases the surv... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-23 |
Journal Detail:
|
Title: International journal of oncology Volume: - ISSN: 1791-2423 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9306042 Medline TA: Int J Oncol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Laboratory of Toxicology, College of Veterinary Medicine Seoul National University, Seoul 151-742, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The visual cortex in schizophrenia: alterations of gyrification rather than cortical thickness-a com...
Next Document: Protein interactions with HER-family receptors can have different characteristics depend...