Document Detail


Carboxyl-ebselen-based layer-by-layer films as potential antithrombotic and antimicrobial coatings.
MedLine Citation:
PMID:  21794909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A carboxyl-ebselen-based layer-by-layer (LbL) film was fabricated by alternatively assembling carboxyl-ebselen immobilized polyethylenimine (e-PEI) and alginate (Alg) onto substrates followed by salt annealing and cross-linking. The annealed films exhibiting significantly improved stability are capable of generating nitric oxide (NO) from endogeneous S-nitrosothiols (RSNOs) in the presence of a reducing agent. The NO generation behaviors of different organoselenium species in solution phase are compared and the annealing mechanism to create stable LbL films is studied in detail. An LbL film coated polyurethane catheter is capable of generating physiological levels of NO from RSNOs even after blood soaking for 24 h, indicating potential antithrombotic applications of the coating. Further, the LbL film is also demonstrated to be capable of reducing living bacterial surface attachment and killing a broad spectrum of bacteria, likely through generation of superoxide (O(2)(·-)) from oxygen. This type of film is expected to have potential application as an antithrombotic and antimicrobial coating for different biomedical device surfaces.
Authors:
Wenyi Cai; Jianfeng Wu; Chuanwu Xi; Arthur J Ashe; Mark E Meyerhoff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-07-26
Journal Detail:
Title:  Biomaterials     Volume:  32     ISSN:  1878-5905     ISO Abbreviation:  Biomaterials     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-08-22     Completed Date:  2011-12-19     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  7774-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Infective Agents / chemistry,  pharmacology*
Antithrombins / chemistry,  pharmacology*
Azoles / chemistry,  pharmacology*
Catalysis / drug effects
Coated Materials, Biocompatible / chemistry,  pharmacology*
Cross-Linking Reagents / pharmacology
Escherichia coli / cytology,  drug effects
Free Radical Scavengers / pharmacology
Microbial Sensitivity Tests
Microbial Viability / drug effects
Microscopy, Electron, Scanning
Microscopy, Fluorescence
Nitric Oxide / chemical synthesis
Organoselenium Compounds / chemistry,  pharmacology*
Polyethyleneimine / pharmacology
S-Nitrosothiols / chemistry
Selenium / chemistry
Sheep
Spectrophotometry, Ultraviolet
Superoxides / chemistry
Grant Support
ID/Acronym/Agency:
EB-004527/EB/NIBIB NIH HHS; R01 EB004527/EB/NIBIB NIH HHS; R01 EB004527-08/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Antithrombins; 0/Azoles; 0/Coated Materials, Biocompatible; 0/Cross-Linking Reagents; 0/Free Radical Scavengers; 0/Organoselenium Compounds; 0/S-Nitrosothiols; 11062-77-4/Superoxides; 153871-75-1/carboxyebselen; 31C4KY9ESH/Nitric Oxide; 40X2P7DPGH/ebselen; 9002-98-6/Polyethyleneimine; H6241UJ22B/Selenium
Comments/Corrections

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