Document Detail

Carboxyhemoglobin levels in neonatal immune hemolytic jaundice treated with intravenous gammaglobulin.
MedLine Citation:
PMID:  8585207     Owner:  NLM     Status:  MEDLINE    
In order to examine the effect of intravenous immunoglobulin (IVIG) on the rate of hemolysis in immune hemolytic hyperbilirubinemia, we measured the carboxyhemoglobin levels of 5 newborn infants who were subjected to IVIG treatment. The pretreatment rate of hemolysis, in the 5 patients with isoimmune hemolytic jaundice (3 patients with Rh hemolytic disease of the newborn and 2 patients with ABO hemolytic disease of the newborn), as reflected by carboxyhemoglobin levels was higher than the rate of hemolysis in normal newborn infants. In 4 out of the 5 patients treated with IVIG, there was a rapid decline ( > 30%) of carboxyhemoglobin levels, a pattern which was different from that observed in normal newborn infants with no hemolytic jaundice and in 3 untreated patients with ABO hemolytic disease of the newborn. None of the treated patients required an exchange transfusion. Our preliminary results support the theory that the attenuation of jaundice observed following IVIG treatment in patients with immune hemolytic hyperbilirubinemia is caused, at least in part, by the reduction in hemolysis.
Z Ergaz; D Gross; B Bar-Oz; O Peleg; I Arad
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Vox sanguinis     Volume:  69     ISSN:  0042-9007     ISO Abbreviation:  Vox Sang.     Publication Date:  1995  
Date Detail:
Created Date:  1996-03-20     Completed Date:  1996-03-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  95-9     Citation Subset:  IM    
Department of Neonatology, Hadassah University Hospital, Jerusalem, Israel.
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MeSH Terms
ABO Blood-Group System / immunology
Carboxyhemoglobin / analysis*
Combined Modality Therapy
Erythroblastosis, Fetal / blood,  complications,  immunology,  therapy*
Immunoglobulins, Intravenous / therapeutic use*
Infant, Newborn
Jaundice, Neonatal / blood,  etiology,  immunology,  therapy*
Rh Isoimmunization / complications
Reg. No./Substance:
0/ABO Blood-Group System; 0/Immunoglobulins, Intravenous; 9061-29-4/Carboxyhemoglobin

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