| Carbonyl sulfide-mediated prebiotic formation of peptides. | |
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MedLine Citation:
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PMID: 15472077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Almost all discussions of prebiotic chemistry assume that amino acids, nucleotides, and possibly other monomers were first formed on the Earth or brought to it in comets and meteorites, and then condensed nonenzymatically to form oligomeric products. However, attempts to demonstrate plausibly prebiotic polymerization reactions have met with limited success. We show that carbonyl sulfide (COS), a simple volcanic gas, brings about the formation of peptides from amino acids under mild conditions in aqueous solution. Depending on the reaction conditions and additives used, exposure of alpha-amino acids to COS generates peptides in yields of up to 80% in minutes to hours at room temperature. |
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Authors:
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Luke Leman; Leslie Orgel; M Reza Ghadiri |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 306 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-10-08 Completed Date: 2004-10-21 Revised Date: 2007-03-19 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 283-6 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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chemistry* Anaerobiosis Cyclization Dipeptides / chemistry Evolution, Chemical* Magnetic Resonance Spectroscopy Oligopeptides / chemistry* Oxidation-Reduction Phenylalanine / chemistry Serine / chemistry Sulfur Oxides / chemistry* Temperature Thermodynamics Thiocarbamates / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Dipeptides; 0/Oligopeptides; 0/Sulfur Oxides; 0/Thiocarbamates; 463-58-1/carbonyl sulfide; 56-45-1/Serine; 63-91-2/Phenylalanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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