Document Detail

Carbonyl sulfide-mediated prebiotic formation of peptides.
MedLine Citation:
PMID:  15472077     Owner:  NLM     Status:  MEDLINE    
Almost all discussions of prebiotic chemistry assume that amino acids, nucleotides, and possibly other monomers were first formed on the Earth or brought to it in comets and meteorites, and then condensed nonenzymatically to form oligomeric products. However, attempts to demonstrate plausibly prebiotic polymerization reactions have met with limited success. We show that carbonyl sulfide (COS), a simple volcanic gas, brings about the formation of peptides from amino acids under mild conditions in aqueous solution. Depending on the reaction conditions and additives used, exposure of alpha-amino acids to COS generates peptides in yields of up to 80% in minutes to hours at room temperature.
Luke Leman; Leslie Orgel; M Reza Ghadiri
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  306     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-08     Completed Date:  2004-10-21     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  283-6     Citation Subset:  IM    
Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
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MeSH Terms
Amino Acids / chemistry*
Dipeptides / chemistry
Evolution, Chemical*
Magnetic Resonance Spectroscopy
Oligopeptides / chemistry*
Phenylalanine / chemistry
Serine / chemistry
Sulfur Oxides / chemistry*
Thiocarbamates / chemistry
Reg. No./Substance:
0/Amino Acids; 0/Dipeptides; 0/Oligopeptides; 0/Sulfur Oxides; 0/Thiocarbamates; 463-58-1/carbonyl sulfide; 56-45-1/Serine; 63-91-2/Phenylalanine

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