Document Detail


Carbonyl reductase 1 as a novel target of (-)-epigallocatechin gallate against hepatocellular carcinoma.
MedLine Citation:
PMID:  20683966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: These results strongly suggest that EGCG can inhibit CBR1 activity and enhance the effectiveness and decrease the cardiotoxicity of the anticancer drug DNR. These findings also indicate that a combination of EGCG and DNR might represent a novel approach for hepatocellular carcinoma therapy or chemoprevention.
Authors:
Weixue Huang; Liya Ding; Qiang Huang; Hairong Hu; Shan Liu; Xianmei Yang; Xiaohui Hu; Yongjun Dang; Suqin Shen; Jie Li; Xiaona Ji; Songmin Jiang; Jun O Liu; Long Yu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  52     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-04     Completed Date:  2010-09-07     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  703-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alcohol Oxidoreductases / antagonists & inhibitors*
Animals
Antibiotics, Antineoplastic / therapeutic use
Anticarcinogenic Agents / pharmacology*,  therapeutic use*
Carcinoma, Hepatocellular / drug therapy*,  enzymology*
Catechin / analogs & derivatives*,  pharmacology,  therapeutic use
Daunorubicin / therapeutic use
Humans
Liver Neoplasms / drug therapy*,  enzymology*
Mice
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Anticarcinogenic Agents; 8R1V1STN48/Catechin; BQM438CTEL/epigallocatechin gallate; EC 1.1.-/Alcohol Oxidoreductases; EC 1.1.1.184/CBR1 protein, human; ZS7284E0ZP/Daunorubicin

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