| Carbonic anhydrase-inhibiting medications and the intracarotid amobarbital procedure in children. | |
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MedLine Citation:
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PMID: 19208439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The intracarotid amobarbital procedure (IAP) is routinely conducted as part of the presurgical evaluation of pediatric patients with epilepsy. The aim of the present study was to investigate the possibility that anesthetization failures are the result of interactions of carbonic anhydrase-inhibiting (CAI) medications with sodium amobarbital. An archival review of 81 cases conducted between 1999 and 2008 was performed across two pediatric epilepsy centers. chi(2) analysis was used to assess whether CAI medications interfered with the outcome of these procedures. Of 81 patients, 85.2% had conclusive findings. All of the remaining 14.8% with anesthetization failures were taking CAI medications at the time of the procedure. However, 53.8% of patients taking CAI medications had conclusive results. This suggests that these medications may interact with sodium amobarbital, raising the possibility of anesthetization failures in children prescribed CAI medications. |
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Authors:
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Thomas G Burns; Gregory P Lee; Megan L McCormick; Ashley N Pettoni; J Robert Flamini; Morris Cohen |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2009-02-08 |
Journal Detail:
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Title: Epilepsy & behavior : E&B Volume: 15 ISSN: 1525-5069 ISO Abbreviation: Epilepsy Behav Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-21 Completed Date: 2009-08-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892858 Medline TA: Epilepsy Behav Country: United States |
Other Details:
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Languages: eng Pagination: 240-4 Citation Subset: IM |
Affiliation:
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Department of Neuropsychology, Epilepsy Center, Children's Healthcare of Atlanta, 1001 Johnson Ferry Road, Atlanta, GA 30342, USA. burns1@mindspring.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age Factors Amobarbital / adverse effects*, diagnostic use* Anesthesia / adverse effects, methods* Anticonvulsants / therapeutic use Carbonic Anhydrase Inhibitors / adverse effects* Child Epilepsy / diagnosis*, drug therapy, surgery Female Functional Laterality / drug effects Humans Male Memory / drug effects Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Carbonic Anhydrase Inhibitors; 57-43-2/Amobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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