Document Detail

Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
MedLine Citation:
PMID:  19464888     Owner:  NLM     Status:  MEDLINE    
An activation study of the membrane-associated carbonic anhydrase (CA, EC isoform XV with a series of natural and non-natural amino acids and aromatic/heterocyclic amines is reported. Murine CA XV was strongly activated by some amino acids (d-Phe, l-/d-DOPA, d-Trp, l-Tyr) and amines (dopamine, serotonin, l-adrenaline and 4-(2-aminoethyl)-morpholine) with activation constants in the range of 4.0-9.5muM. l-/d-His, l-Phe, histamine and several other heterocyclic amines showed less efficient activation (K(A)s in the range of 11.6-33.4muM). The activation profile of CA XV is quite different from that of the cytosolic isoforms CA I and II or the membrane-associated CA IV. All mammalian isoforms CA I-XV are thus characterized for their interaction with this set of amino acid and amine activators, some of which are biogenic amines or neurotransmitters present in sufficiently high amounts in various tissues for exerting significant biologic responses.
Alessio Innocenti; Mika Hilvo; Seppo Parkkila; Andrea Scozzafava; Claudiu T Supuran
Related Documents :
22095008 - Historical impact to drive research in peptic ulcer disease.
3625708 - Phosphorus amino acid analogues as inhibitors of leucine aminopeptidase.
7586058 - Structure-activity relationships of neuromedin u. i. contractile activity of dog neurom...
3012488 - Antinociceptive effects in rodents of the dipeptide lys-trp (nps) and related compounds.
1611658 - Effect of epidermal growth factor on ornithine decarboxylase activity and urea synthesi...
21669528 - Identification of non-amidine inhibitors of acid-sensing ion channel-3 (asic3).
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-12
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  19     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-09     Completed Date:  2009-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  3430-3     Citation Subset:  IM    
Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino, Firenze, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amines / chemistry*
Amino Acid Sequence
Amino Acids / chemistry*
Carbonic Anhydrases / chemistry,  metabolism*
Enzyme Activators / chemistry,  metabolism*
Molecular Sequence Data
Protein Isoforms / chemistry,  metabolism
Recombinant Proteins / chemistry,  metabolism
Sequence Homology, Amino Acid
Structure-Activity Relationship
Reg. No./Substance:
0/Amines; 0/Amino Acids; 0/Enzyme Activators; 0/Protein Isoforms; 0/Recombinant Proteins; EC Anhydrases; EC anhydrase XV, mouse

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Aminoquinoline derivatives with antiproliferative activity against melanoma cell line.
Next Document:  Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.