Document Detail

Carbonated beverages and urinary calcium excretion.
MedLine Citation:
PMID:  11522558     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intake of carbonated beverages has been associated with increased fracture risk in observational studies. The usual explanation given is that one or more of the beverage constituents increase urinary calcium. OBJECTIVE: We assessed the short-term effects on urinary calcium excretion of carbonated beverages of various compositions. DESIGN: An incomplete random block design was used to study 20-40-y-old women who customarily consumed > or =680 mL carbonated beverages daily. Four carbonated beverages were tested: 2 with caffeine and 2 without. Two contained phosphoric acid as the acidulant and 2 contained citric acid. The study included one neutral control (water) and one positive control (skim or chocolate milk). Serving size was 567 mL for the carbonated beverages and water and 340 mL for the milks. Beverages were consumed with a light breakfast after an overnight fast; no other foods were ingested until urine collection was complete. pH, titratable and total acidity, sodium, creatinine, and calcium were measured in 2-h (morning) fasting and 5-h postbeverage urine specimens. RESULTS: Relative to water, urinary calcium rose significantly only with the milks and the 2 caffeine-containing beverages. The excess calciuria was approximately 0.25 mmol, about the same as previously reported for caffeine alone. Phosphoric acid without caffeine produced no excess calciuria; nor did it augment the calciuria of caffeine. CONCLUSIONS: The excess calciuria associated with consumption of carbonated beverages is confined to caffeinated beverages. Acidulant type has no acute effect. Because the caffeine effect is known to be compensated for by reduced calciuria later in the day, we conclude that the net effect of carbonated beverage constituents on calcium economy is negligible. The skeletal effects of carbonated beverage consumption are likely due primarily to milk displacement.
R P Heaney; K Rafferty
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  74     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-08-27     Completed Date:  2001-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  343-7     Citation Subset:  AIM; IM    
Creighton University Osteoporosis Research Center, Omaha, NE 68131, USA.
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MeSH Terms
Caffeine / adverse effects*
Calcium / metabolism,  urine*
Carbonated Beverages / adverse effects,  analysis*
Citric Acid / administration & dosage
Creatinine / urine
Fractures, Bone / etiology*,  metabolism
Hydrogen-Ion Concentration
Phosphoric Acids / administration & dosage
Risk Factors
Sodium / urine
Reg. No./Substance:
0/Phosphoric Acids; 58-08-2/Caffeine; 60-27-5/Creatinine; 7440-23-5/Sodium; 7440-70-2/Calcium; 7664-38-2/phosphoric acid; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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