| Carbon nanotubes induce granulomas but not mesotheliomas. | |
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MedLine Citation:
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PMID: 20363987 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Different types of carbon nanotubes may represent toxic hazards due to their size distribution and massive surface area. They may adsorb other toxic agents that can consequently be transported into the body. Hence the aim of this study was to confirm or reject the hypothesis of carcinogenicity of two types of carbon nanotubes. MATERIALS AND METHODS: Well-defined single-walled and multi-walled carbon nanotubes were studied in a specific animal model for mesothelioma induction. RESULTS: Short-term pilot studies were published on the asbestos fibre-like mesothelioma-inducing effects of carbon nanotubes based on the proposed mechanistic correlation on health effects of fibres of the same size. Our results with a simple in vivo, peritoneal exposure model refute such an interpretation. The present studies with rats indicate that early granuloma formation does not lead to the development of mesotheliomas during chronic exposure of peritoneal mesothelium to either single- or multi-walled carbon nanotubes of varied size. CONCLUSION: Due to the limited toxicity data on carbon nanotubes, these results may be particularly important for risk assessment purposes. |
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Authors:
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Csaba Varga; Katalin Szendi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: In vivo (Athens, Greece) Volume: 24 ISSN: 0258-851X ISO Abbreviation: In Vivo Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-05-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8806809 Medline TA: In Vivo Country: Greece |
Other Details:
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Languages: eng Pagination: 153-6 Citation Subset: IM |
Affiliation:
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Department of Environmental Health, Institute of Public Health Medicine, University of P?cs, P?cs, 7624 Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Disease Progression Granuloma / chemically induced*, epidemiology, pathology Mesothelioma / chemically induced*, epidemiology, pathology Nanotubes, Carbon / toxicity* Peritoneal Neoplasms / chemically induced*, epidemiology, pathology Rats Risk Assessment Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Nanotubes, Carbon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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