Document Detail


Carbon nanotube-coupled cell adhesion peptides are non-immunogenic: a promising step toward new biomedical devices.
MedLine Citation:
PMID:  20853522     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Carbon nanotubes functionalized with cell adhesion peptides can be considered as novel, promising candidates for the development of advanced drug delivery systems or for designing new generation of self-assembling nerve 'bridges'. An important step toward the integration of these types of conjugates in living bodies is the assessment of their impact on the immune system. In this direction, an integrin-derived peptide has been covalently conjugated to carbon nanotubes. Following intraperitoneal administration, peptide-carbon nanotubes do not trigger an anti-peptide antibody production. Demonstration of the immune neutrality of peptide-carbon nanotubes reinforces their potential use as substrates for neuronal regeneration in vivo.
Authors:
Claire Gaillard; Monique Duval; Hélène Dumortier; Alberto Bianco
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-20
Journal Detail:
Title:  Journal of peptide science : an official publication of the European Peptide Society     Volume:  17     ISSN:  1099-1387     ISO Abbreviation:  J. Pept. Sci.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506309     Medline TA:  J Pept Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  139-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd.
Affiliation:
CNRS, Institut de Biologie Moléculaire et Cellulaire, UPR 9021, Immunologie et Chimie Thérapeutiques, 67000 Strasbourg, France.
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