| Carbon monoxide-prostaglandin E2 interaction in the hypothalamic circulation. | |
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MedLine Citation:
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PMID: 18815586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The heme oxygenase (HO)-carbon monoxide pathway was earlier shown to increase hypothalamic blood flow after inhibition of nitric oxide synthesis in rats. We hypothesized that this effect is mediated by prostaglandin E2 (PGE2). Inhibition of constitutive HO activity decreased cerebral PGE2 production and simultaneously increased hypothalamic nitric oxide synthase (NOS) activity without changing hypothalamic blood flow. Furthermore, HO blockade induced cyclooxygenase-dependent decrease and NOS-mediated increase of the hypothalamic blood flow after inhibition of NOS and cyclooxygenase, respectively. Therefore, constitutive carbon monoxide release seems to have two indirect effects on the hypothalamic circulation: vasodilation mediated by PGE2 and vasoconstriction as a result of NOS inhibition. |
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Authors:
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Béla Horváth; László Hortobágyi; Gábor Lenzsér; Horst Schweer; András Hrabák; Péter Sándor; Zoltán Benyó |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroreport Volume: 19 ISSN: 1473-558X ISO Abbreviation: Neuroreport Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-10 Completed Date: 2008-11-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 1601-4 Citation Subset: IM |
Affiliation:
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Institute of Human Physiology and Clinical Experimental Research, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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cerebrospinal fluid,
metabolism Animals Blood Gas Analysis / methods Blood Pressure / drug effects, physiology Carbon Monoxide / metabolism* Cyclooxygenase Inhibitors / administration & dosage, pharmacology Deuteroporphyrins / administration & dosage, pharmacology Diclofenac / administration & dosage, pharmacology Dinoprost / cerebrospinal fluid, metabolism Dinoprostone / cerebrospinal fluid, metabolism* Enzyme Inhibitors / administration & dosage, pharmacology Heart Rate / drug effects, physiology Heme Oxygenase (Decyclizing) / antagonists & inhibitors, metabolism* Hypothalamus / blood supply*, drug effects, metabolism Injections, Intraperitoneal Injections, Intravenous Male NG-Nitroarginine Methyl Ester / administration & dosage, pharmacology Prostaglandin D2 / cerebrospinal fluid, metabolism Prostaglandin-Endoperoxide Synthases / metabolism Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Cyclooxygenase Inhibitors; 0/Deuteroporphyrins; 0/Enzyme Inhibitors; 119700-81-1/zinc deuteroporphyrin IX 2,4-bis(glycol); 15307-86-5/Diclofenac; 363-24-6/Dinoprostone; 41598-07-6/Prostaglandin D2; 50903-99-6/NG-Nitroarginine Methyl Ester; 551-11-1/Dinoprost; 58962-34-8/6-Ketoprostaglandin F1 alpha; 630-08-0/Carbon Monoxide; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases; EC 1.14.99.3/Heme Oxygenase (Decyclizing) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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