Document Detail


Carbon monoxide and pancreatic islet blood flow in the rat: inhibition of haem oxygenase does not affect islet blood perfusion.
MedLine Citation:
PMID:  17101545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether carbon monoxide, a known gaseous vasorelaxator, affects pancreatic islet blood flow in rats. MATERIAL AND METHODS: Sprague-Dawley rats were anaesthetized with thiobutabarbital and injected intravenously with the haem oxygenase inhibitor tin-protoporphyrin IX dichloride (SnPP; 4, 10 or 20 mg/kg body-weight). After 15 min, blood flow measurements were performed using a microsphere technique. RESULTS: There was a slight increase in mean arterial blood pressure with the highest dose of SnPP. No effects on total pancreatic, islet, duodenal, colonic, renal or adrenal blood flow were seen with any of the applied doses. CONCLUSIONS: The findings of this study suggest that the haem oxygenase-carbon monoxide system is likely to be of limited importance in the regulation of blood perfusion to the pancreas, the islets of Langerhans or any of the other studied organs.
Authors:
P-O Carlsson; B Bodin; A Andersson; L Jansson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  66     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2006  
Date Detail:
Created Date:  2006-11-14     Completed Date:  2007-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  543-8     Citation Subset:  IM    
Affiliation:
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Carbon Monoxide / pharmacology*
Enzyme Inhibitors / pharmacology
Heme Oxygenase (Decyclizing) / antagonists & inhibitors*
Islets of Langerhans / blood supply*
Male
Metalloporphyrins / pharmacology
Protoporphyrins / pharmacology
Rats
Rats, Sprague-Dawley
Regional Blood Flow / drug effects
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Metalloporphyrins; 0/Protoporphyrins; 0/Vasodilator Agents; 14325-05-4/tin protoporphyrin IX; 630-08-0/Carbon Monoxide; EC 1.14.99.3/Heme Oxygenase (Decyclizing)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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