| Carbon monoxide intoxication during pregnancy: a case presentation and pathophysiologic discussion, with emphasis on molecular mechanisms. | |
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MedLine Citation:
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PMID: 7772366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In carbon monoxide (CO) poisoning, the mortality and morbidity risk does not always correlate with the level of carboxyhemoglobin (COHb). Recent studies confirm that the mitochondrial cytochrome portion of the respiratory chain is susceptible to CO toxicity at concentrations traditionally considered nontoxic. These laboratory findings correlate with subtle neurologic symptoms detected by psychometric studies in individuals many days from the time of acute intoxication. Additionally, in the pregnant patient, a time lag for both uptake and elimination of CO between the mother and fetus has been demonstrated, with the fetus at risk for hypoxia even when the mother's blood level of CO is nontoxic. Hyperbaric oxygen (HBO) therapy in pregnant patients has not been shown to have adverse effects on the fetus. We present a case of CO intoxication in late pregnancy treated with HBO therapy without adverse consequences. |
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Authors:
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A Gabrielli; A J Layon |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of clinical anesthesia Volume: 7 ISSN: 0952-8180 ISO Abbreviation: J Clin Anesth Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-07-13 Completed Date: 1995-07-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8812166 Medline TA: J Clin Anesth Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 82-7 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, University of Florida College of Medicine, Gainesville 32610-0254, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anoxia / blood Carbon Monoxide / blood Carbon Monoxide Poisoning / blood, diagnosis*, physiopathology, therapy Carboxyhemoglobin / analysis Female Fetal Blood / chemistry Humans Hyperbaric Oxygenation Maternal-Fetal Exchange Pregnancy Pregnancy Complications / blood, diagnosis*, physiopathology, therapy |
| Chemical | |
Reg. No./Substance:
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630-08-0/Carbon Monoxide; 9061-29-4/Carboxyhemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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