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Carbon monoxide: A gas that modulates nociception.
MedLine Citation:
PMID:  21425317     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Carbon monoxide (CO) has been recognized to act as an atypical neurotransmitter or neuromodulator in the nervous system and to be involved in a wide variety of neuronal activities. Several lines of evidence suggest that CO may play a role through multiple mechanisms in nociception processing. Differential regulation of a family of CO-generating enzymes, heme oxygenase (HO), contributes mainly to the complexity underlying the role of CO in nociception. This Mini-Review describes the latest evidence for the role of CO during normal sensory transmission and pathological pain conditions and discusses potential cellular mechanisms by which CO is involved in pathological pain. © 2011 Wiley-Liss, Inc.
Authors:
Wenguo Fan; Fang Huang; Zhi Wu; Xiao Zhu; Dongpei Li; Hongwen He
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-21
Journal Detail:
Title:  Journal of neuroscience research     Volume:  -     ISSN:  1097-4547     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600111     Medline TA:  J Neurosci Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Affiliation:
Department of Oral Anatomy and Physiology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.
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