Document Detail


Carbon monoxide form of PEGylated hemoglobin protects myocardium against ischemia/reperfusion injury in diabetic and normal mice.
MedLine Citation:
PMID:  23342967     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We investigated the pre-clinical utility of carbon monoxide form of PEGylated hemoglobin (PEG-Hb also named SANGUINATE(™)) in myocardial infarction (MI) and in particular the response of diabetic tissues to superimposed ischemia/reperfusion injury. SANGUINATE(™) was evaluated in diabetic and normal mice subjected to 30 min of coronary artery ligation followed by either 48 h or 28 days of reperfusion. Our results demonstrate that SANGUINATE(™) was effective in reducing infarct size when administered either prior to left anterior descending coronary artery (LAD) occlusion or during reperfusion. This finding is an important step in exploring the efficacy of a pharmacoinvasive strategy using SANGUINATE(™) in patients with acute coronary syndromes.
Authors:
Radha Ananthakrishnan; Qing Li; Karen M O'Shea; Nosirudeen Quadri; Lingjie Wang; Abraham Abuchowski; Ann Marie Schmidt; Ravichandran Ramasamy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-23
Journal Detail:
Title:  Artificial cells, nanomedicine, and biotechnology (Print)     Volume:  -     ISSN:  2169-141X     ISO Abbreviation:  Artif Cells Nanomed Biotechnol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101594777     Medline TA:  Artif Cells Nanomed Biotechnol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Medicine, Diabetes Research Program, New York University Langone Medical Center, New York , NY , USA.
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