Document Detail

Carbon monoxide brain toxicity: clinical, magnetic resonance imaging, magnetic resonance spectroscopy, and neuropsychological effects in 9 people.
MedLine Citation:
PMID:  15746226     Owner:  NLM     Status:  MEDLINE    
Carbon monoxide (CO) exposure is a common cause of toxic brain damage, whereby effects range from transient neurological dysfunction to coma and death. A spectrum of severity of magnetic resonance imaging (MRI) findings after CO brain toxicity, including globus pallidus and white matter lesions, is well documented. Reports of MR spectroscopy (MRS) findings re main sparse. This article reports 9 people exposed to CO because of an apartment house's faulty gas heater. Four, with transient loss of consciousness after chronic moderate level CO exposure, suffered intellectual impairment without MRI abnormalities. The MRS of 1 individual demonstrated decreased n-acetyl aspartase in the basal ganglia, bilaterally. Of 5 exposed to high levels for about 12 hours, 1 died prior to clinical and/or MRI evaluation. One who suffered coma recovered but was lost to evaluation. Three, who were unconscious for hours to days, exhibited T2 MRI white matter signal abnormalities. MRS showed decreased basal ganglia n-acetyl aspartase in 2. One of these suffers a Parkinsonian syndrome. All 3 are intellectually impaired. This study demonstrates that although MRI and MRS are useful markers of CO-induced brain damage, they are not always sensitive to resultant intellectual dysfunction.
Leon D Prockop
Related Documents :
11251706 - Hypertensive encephalopathy presenting with thunderclap headache.
16425546 - Hypertensive encephalopathy involving the brainstem and deep structures: a case report.
11214916 - Histopathology and immunohistochemistry of human transmissible spongiform encephalopath...
20630716 - Size of basal ganglia in suicide attempters, and its association with temperament and s...
21975576 - Incidental computed tomography sacroiliitis: clinical significance and inappropriatenes...
10363446 - Tolosa hunt syndrome: a case report. clinical and magnetic resonance imaging findings.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  15     ISSN:  1051-2284     ISO Abbreviation:  J Neuroimaging     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-04     Completed Date:  2005-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  144-9     Citation Subset:  IM    
Department of Neurology, College of Medicine, University of South Florida, Tampa 33612, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Aspartic Acid / analogs & derivatives*,  analysis
Basal Ganglia / chemistry
Brain / physiopathology*
Carbon Monoxide Poisoning / complications,  physiopathology*
Chronic Disease
Cognition / physiology
Coma / etiology,  physiopathology
Comprehension / physiology
Magnetic Resonance Imaging*
Magnetic Resonance Spectroscopy*
Mental Processes / physiology*
Neuropsychological Tests
Parkinson Disease, Secondary / etiology,  physiopathology
Thinking / physiology
Unconsciousness / etiology
Reg. No./Substance:
56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bedside emergency transcranial Doppler diagnosis of severe carotid disease using orbital window exam...
Next Document:  Localized cerebral blood flow reductions in patients with heart failure: a study using 99mTc-HMPAO S...