Document Detail


Carbon monoxide brain toxicity: clinical, magnetic resonance imaging, magnetic resonance spectroscopy, and neuropsychological effects in 9 people.
MedLine Citation:
PMID:  15746226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carbon monoxide (CO) exposure is a common cause of toxic brain damage, whereby effects range from transient neurological dysfunction to coma and death. A spectrum of severity of magnetic resonance imaging (MRI) findings after CO brain toxicity, including globus pallidus and white matter lesions, is well documented. Reports of MR spectroscopy (MRS) findings re main sparse. This article reports 9 people exposed to CO because of an apartment house's faulty gas heater. Four, with transient loss of consciousness after chronic moderate level CO exposure, suffered intellectual impairment without MRI abnormalities. The MRS of 1 individual demonstrated decreased n-acetyl aspartase in the basal ganglia, bilaterally. Of 5 exposed to high levels for about 12 hours, 1 died prior to clinical and/or MRI evaluation. One who suffered coma recovered but was lost to evaluation. Three, who were unconscious for hours to days, exhibited T2 MRI white matter signal abnormalities. MRS showed decreased basal ganglia n-acetyl aspartase in 2. One of these suffers a Parkinsonian syndrome. All 3 are intellectually impaired. This study demonstrates that although MRI and MRS are useful markers of CO-induced brain damage, they are not always sensitive to resultant intellectual dysfunction.
Authors:
Leon D Prockop
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  15     ISSN:  1051-2284     ISO Abbreviation:  J Neuroimaging     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-04     Completed Date:  2005-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  144-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, College of Medicine, University of South Florida, Tampa 33612, USA. lprockop@hsc.usf.edu
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Aspartic Acid / analogs & derivatives*,  analysis
Basal Ganglia / chemistry
Brain / physiopathology*
Carbon Monoxide Poisoning / complications,  physiopathology*
Child
Chronic Disease
Cognition / physiology
Coma / etiology,  physiopathology
Comprehension / physiology
Female
Humans
Magnetic Resonance Imaging*
Magnetic Resonance Spectroscopy*
Male
Mental Processes / physiology*
Neuropsychological Tests
Parkinson Disease, Secondary / etiology,  physiopathology
Thinking / physiology
Unconsciousness / etiology
Chemical
Reg. No./Substance:
56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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