Document Detail

Carbon dioxide respiratory response during positive inspiratory pressure in COPD patients.
MedLine Citation:
PMID:  9271805     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to compare the effect of inspiratory pressure support (IPS) on the respiratory CO2 response in 13 stable COPD patients and in 13 normal subjects. Without IPS, the slopes of the ventilatory response to CO2 were lower in the patients than in the normal subjects (mean +/- SEM, 0.82 +/- 0.19 vs. 1.69 +/- 0.31 l.min-1.mmHg-1). When IPS was applied, both groups showed, at any level of end-tidal CO2 pressure, an increase in ventilation due to an increase in tidal volume (VT) associated with a decrease in occlusion pressure (P0.1). In addition, respiratory parameters (VE, VT, P0.1, inspiratory flow) were insensitive to CO2 as long as PETCO2 remained below a threshold which was slightly above the eupneic value. However, above this CO2-threshold, no differences in slopes were observed between the IPS and control conditions in either group, except for a decrease in the P0.1 slope during IPS in the COPD patients. In conclusion, IPS induced similar respiratory changes during CO2 response in stable COPD patients and in normal subjects. Above the eupneic value, IPS did not change the slope of the ventilatory response to CO2.
L Heyer; H Lorino; C Delclaux; D Isabey; A Harf; F Lofaso
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  109     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  29-37     Citation Subset:  IM    
Service de Physiologie-Explorations Fonctionnelles, Hôpital Henri Mondor, Créteil, France.
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MeSH Terms
Carbon Dioxide / pharmacology*
Lung Diseases, Obstructive / physiopathology*
Middle Aged
Pulmonary Ventilation / physiology*
Respiration / drug effects*
Reg. No./Substance:
124-38-9/Carbon Dioxide

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