Document Detail

Carbon-carbon bond cleavage by cytochrome p450(BioI)(CYP107H1).
MedLine Citation:
PMID:  14737344     Owner:  NLM     Status:  MEDLINE    
Cytochrome p450(BioI)(CYP107H1) is believed to supply pimelic acid equivalents for biotin biosynthesis in Bacillus subtilis: we report here that the mechanistic pathway adopted by this multifunctional p450 for the in-chain cleavage of fatty acids is via consecutive formation of alcohol and threo-diol intermediates, with the likely absolute configuration of the intermediates also reported.
Max J Cryle; James J De Voss
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Publication Detail:
Type:  Journal Article     Date:  2003-11-17
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1359-7345     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-22     Completed Date:  2004-09-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  86-7     Citation Subset:  IM    
Department of Chemistry, University of Queensland, St. Lucia, Brisbane, Australia 4072.
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MeSH Terms
Bacillus subtilis / enzymology*
Bacterial Proteins / metabolism*
Carbon / chemistry
Cytochrome P-450 Enzyme System / metabolism*
Escherichia coli / enzymology
Fatty Acids / chemistry,  metabolism*
Myristic Acid / chemistry,  metabolism
Pimelic Acids / chemistry,  metabolism
Reg. No./Substance:
0/Bacterial Proteins; 0/Fatty Acids; 0/Pimelic Acids; 544-63-8/Myristic Acid; 7440-44-0/Carbon; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.14.-/CYP107H1, Bacillus subtilis

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