Document Detail


Carbon-by-carbon discrimination of 13C incorporation into liver fatty acids.
MedLine Citation:
PMID:  1633886     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quantitative carbon-by-carbon analysis would be useful in determining the origin and fate of carbons involved in fatty acid metabolism. Incorporation of 13C from 2-[13C]acetate into specific carbons of liver fatty acids was lowest at the n-2 carbon of saturates and monoenes but was 47% greater at acyl C1 than at C2, suggesting substantial redistribution of the 13C from C2 to C1 of acetyl CoA or malonyl CoA prior to 13C incorporation into fatty acids during de novo synthesis or during elongation. Thus, 13C derived from exogenous acetate can be quantitatively measured and is differentially incorporated into individual carbons depending on position in the fatty acid molecule.
Authors:
S C Cunnane
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  306     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-27     Completed Date:  1992-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  273-5     Citation Subset:  IM    
Affiliation:
Department of Nutritional Sciences, Faculty of Medicine University of Toronto, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon / analysis*,  metabolism
Fatty Acids / chemistry*,  metabolism
Liver / metabolism*
Magnetic Resonance Spectroscopy
Male
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Fatty Acids; 7440-44-0/Carbon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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