Document Detail


Carbon and nitrogen stable isotope ratios predict intake of sweeteners in a Yup'ik study population.
MedLine Citation:
PMID:  23256142     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The carbon isotope ratio (δ¹³C) is elevated in corn- and cane sugar-based foods and has recently shown associations with sweetener intake in multiple U.S. populations. However, a high carbon isotope ratio is not specific to corn- and sugar cane-based sweeteners, as other foods, including meats and fish, also have elevated δ¹³C. This study examines whether the inclusion of a second marker, the nitrogen isotope ratio (δ¹⁵N), can control for confounding dietary effects on δ¹³C and improve the validity of isotopic markers of sweetener intake. The study participants are from the Yup'ik population of southwest Alaska and consume large and variable amounts of fish and marine mammals known to have elevated carbon and nitrogen isotope ratios. Sixty-eight participants completed 4 weekly 24-h recalls followed by a blood draw. RBC δ¹³C and δ¹⁵N were used to predict sweetener intake, including total sugars, added sugars, and sugar-sweetened beverages. A model including both δ¹³C and δ¹⁵N explained more than 3 times as much of the variation in sweetener intake than did a model using only δ¹³C. Because carbon and nitrogen isotope ratios are simultaneously determined in a single, high-throughput analysis, this dual isotope marker provides a simple method to improve the validity of stable isotope markers of sweetener intake with no additional cost. We anticipate that this multi-isotope approach will have utility in any population where a stable isotope biomarker is elevated in several food groups and there are appropriate "covariate" isotopes to control for intake of foods not of research interest.
Authors:
Sarah H Nash; Alan R Kristal; Andrea Bersamin; Scarlett E Hopkins; Bert B Boyer; Diane M O'Brien
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-12-19
Journal Detail:
Title:  The Journal of nutrition     Volume:  143     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-03-12     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  161-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Alaska
Beverages / analysis
Biological Markers / blood
Carbon Isotopes
Diet* / ethnology
Erythrocytes / metabolism*
Female
Humans
Indians, North American
Male
Middle Aged
Models, Biological*
Nitrogen Isotopes
Nutrition Assessment
Sweetening Agents / administration & dosage*,  analysis
Young Adult
Grant Support
ID/Acronym/Agency:
P20 RR016430/RR/NCRR NIH HHS; P20RR016430/RR/NCRR NIH HHS; P30 GM103325/GM/NIGMS NIH HHS; R01 DK074842/DK/NIDDK NIH HHS; R01DK07442/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Carbon Isotopes; 0/Nitrogen Isotopes; 0/Sweetening Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Vitamin D Status in Montreal Preschoolers Is Satisfactory Despite Low Vitamin D Intake.
Next Document:  The change in plasma 25-hydroxyvitamin D did not differ between breast-fed infants that received a d...