Document Detail


Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells.
MedLine Citation:
PMID:  21657258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process.
Authors:
Liying Wang; Sudjit Luanpitpong; Vincent Castranova; William Tse; Yongju Lu; Varisa Pongrakhananon; Yon Rojanasakul
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2011-06-09
Journal Detail:
Title:  Nano letters     Volume:  11     ISSN:  1530-6992     ISO Abbreviation:  Nano Lett.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-13     Completed Date:  2011-11-22     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101088070     Medline TA:  Nano Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2796-803     Citation Subset:  IM    
Affiliation:
Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Cell Transformation, Neoplastic / metabolism,  pathology*
Epithelial Cells / metabolism,  pathology*
Humans
Lung / metabolism,  pathology*
Mice
Mice, Nude
Nanotechnology
Nanotubes, Carbon / chemistry*
Particle Size
Surface Properties
Tumor Suppressor Protein p53 / metabolism
Grant Support
ID/Acronym/Agency:
R01 HL095579-01A2/HL/NHLBI NIH HHS; R01-HL095579/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Nanotubes, Carbon; 0/Tumor Suppressor Protein p53
Comments/Corrections

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